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A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida
BACKGROUND: Florida Firefighters experience a higher risk of thyroid cancer than non-firefighters. This study examines whether the histologic types and tumor stage of thyroid cancer is different among firefighters compared to other occupational groups. METHODS: Eligible cases were firefighters (n = ...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438132/ https://www.ncbi.nlm.nih.gov/pubmed/36056343 http://dx.doi.org/10.1186/s12902-022-01104-5 |
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author | Ogunsina, Kemi Koru-Sengul, Tulay Rodriguez, Valentina Caban-Martinez, Alberto J. Schaefer-Solle, Natasha Ahn, Soyeon Kobetz, Erin N. Hernandez, Monique N. Lee, David J. |
author_facet | Ogunsina, Kemi Koru-Sengul, Tulay Rodriguez, Valentina Caban-Martinez, Alberto J. Schaefer-Solle, Natasha Ahn, Soyeon Kobetz, Erin N. Hernandez, Monique N. Lee, David J. |
author_sort | Ogunsina, Kemi |
collection | PubMed |
description | BACKGROUND: Florida Firefighters experience a higher risk of thyroid cancer than non-firefighters. This study examines whether the histologic types and tumor stage of thyroid cancer is different among firefighters compared to other occupational groups. METHODS: Eligible cases were firefighters (n = 120) identified in a linkage of Florida Cancer Data System (FCDS) registry records (1981–2014) and Florida State Fire Marshal’s Office employment and certification records, and non-firefighters classified into: blue-collar (n = 655), service (n = 834), white-collar (n = 4,893), and other (n = 1,789). Differences in thyroid histologic type (papillary, follicular, and rare/other less common forms of thyroid cancer), tumor stage, and age at diagnosis were evaluated using multinomial logistic regression models comparing blue-collar, service, white-collar, and other occupational groups with firefighters. Univariate odds ratios as well as odds ratios adjusted for age, gender, race, tumor stage, and year of diagnosis (aOR) and 95% confidence intervals (95%CI) were reported. RESULTS: Service (aOR = 4.12; 95%CI: 1.25—13.65), white-collar (aOR = 3.51; 95%CI: 1.08—11.36), and blue-collar (aOR = 4.59; 95%CI: 1.40—15.07) workers had significantly higher odds of being diagnosed with rare histologic types of thyroid cancer vs papillary type compared to firefighters. Service (aOR = 0.42; 95%CI: 0.27—0.66), white-collar (aOR = 0.39; 95%CI: 0.26—0.59), blue-collar (aOR = 0.36; 95%CI: 0.23—0.56), and other (aOR = 0.34; 95%CI: 0.22—0.53) occupational groups have a significantly lower odds of being diagnosed with rare vs papillary type at a younger age (30—49 years) vs 50—69 years compared to firefighters. However, stage at diagnosis was not significantly different among occupational groups. CONCLUSION: Firefighters diagnosed with thyroid cancer experience a higher odds of papillary compared to rare histologic types of thyroid cancer relative to other workers; there is no evidence of an increased odds of late-stage diagnosis in firefighters relative to other worker groups. Firefighters may benefit from routine screening and active surveillance of suspected thyroid tumors especially given the excellent treatment outcomes available for those diagnosed with early-stage papillary thyroid tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-022-01104-5. |
format | Online Article Text |
id | pubmed-9438132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94381322022-09-03 A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida Ogunsina, Kemi Koru-Sengul, Tulay Rodriguez, Valentina Caban-Martinez, Alberto J. Schaefer-Solle, Natasha Ahn, Soyeon Kobetz, Erin N. Hernandez, Monique N. Lee, David J. BMC Endocr Disord Research BACKGROUND: Florida Firefighters experience a higher risk of thyroid cancer than non-firefighters. This study examines whether the histologic types and tumor stage of thyroid cancer is different among firefighters compared to other occupational groups. METHODS: Eligible cases were firefighters (n = 120) identified in a linkage of Florida Cancer Data System (FCDS) registry records (1981–2014) and Florida State Fire Marshal’s Office employment and certification records, and non-firefighters classified into: blue-collar (n = 655), service (n = 834), white-collar (n = 4,893), and other (n = 1,789). Differences in thyroid histologic type (papillary, follicular, and rare/other less common forms of thyroid cancer), tumor stage, and age at diagnosis were evaluated using multinomial logistic regression models comparing blue-collar, service, white-collar, and other occupational groups with firefighters. Univariate odds ratios as well as odds ratios adjusted for age, gender, race, tumor stage, and year of diagnosis (aOR) and 95% confidence intervals (95%CI) were reported. RESULTS: Service (aOR = 4.12; 95%CI: 1.25—13.65), white-collar (aOR = 3.51; 95%CI: 1.08—11.36), and blue-collar (aOR = 4.59; 95%CI: 1.40—15.07) workers had significantly higher odds of being diagnosed with rare histologic types of thyroid cancer vs papillary type compared to firefighters. Service (aOR = 0.42; 95%CI: 0.27—0.66), white-collar (aOR = 0.39; 95%CI: 0.26—0.59), blue-collar (aOR = 0.36; 95%CI: 0.23—0.56), and other (aOR = 0.34; 95%CI: 0.22—0.53) occupational groups have a significantly lower odds of being diagnosed with rare vs papillary type at a younger age (30—49 years) vs 50—69 years compared to firefighters. However, stage at diagnosis was not significantly different among occupational groups. CONCLUSION: Firefighters diagnosed with thyroid cancer experience a higher odds of papillary compared to rare histologic types of thyroid cancer relative to other workers; there is no evidence of an increased odds of late-stage diagnosis in firefighters relative to other worker groups. Firefighters may benefit from routine screening and active surveillance of suspected thyroid tumors especially given the excellent treatment outcomes available for those diagnosed with early-stage papillary thyroid tumors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-022-01104-5. BioMed Central 2022-09-02 /pmc/articles/PMC9438132/ /pubmed/36056343 http://dx.doi.org/10.1186/s12902-022-01104-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ogunsina, Kemi Koru-Sengul, Tulay Rodriguez, Valentina Caban-Martinez, Alberto J. Schaefer-Solle, Natasha Ahn, Soyeon Kobetz, Erin N. Hernandez, Monique N. Lee, David J. A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida |
title | A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida |
title_full | A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida |
title_fullStr | A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida |
title_full_unstemmed | A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida |
title_short | A comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in Florida |
title_sort | comparative analysis of histologic types of thyroid cancer between career firefighters and other occupational groups in florida |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438132/ https://www.ncbi.nlm.nih.gov/pubmed/36056343 http://dx.doi.org/10.1186/s12902-022-01104-5 |
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