Multicentre single-arm phase II trial evaluating the safety and effiCacy of Panitumumab and iRinOtecan in NeoRAS Wild-type mEtaStatic colorectal cancer patientS (C-PROWESS trial): study protocol

INTRODUCTION: A new concept of ‘NeoRAS wild-type (WT)’, which means conversion of RAS status from RAS mutant to RAS WT after treatment, has been reported. Previous observational and proof-of-concept studies have demonstrated the efficacy of epidermal growth factor receptor inhibitors in patients wit...

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Detalles Bibliográficos
Autores principales: Osumi, Hiroki, Ishizuka, Naoki, Takashima, Atsuo, Kumekawa, Yosuke, Nakano, Daisuke, Shiozawa, Manabu, Denda, Tadamichi, Sawada, Ryoichi, Ouchi, Kota, Wakatsuki, Takeru, Narikazu, Boku, Kato, Ken, Yamaguchi, Kensei, Shinozaki, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438189/
https://www.ncbi.nlm.nih.gov/pubmed/36581973
http://dx.doi.org/10.1136/bmjopen-2022-063071

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