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Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study

INTRODUCTION: Mild traumatic brain injury (mTBI) is one of the most common reasons for emergency department (ED) visits. A portion of patients with mTBI will develop an intracranial lesion that might require medical or surgical intervention. In these patients, swift diagnosis and management is param...

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Autores principales: Fletcher‑Sandersjöö, Alexander, Tatter, Charles, Yang, Li, Pontén, Emeli, Boman, Magnus, Lassarén, Philipp, Forsberg, Sune, Grönlund, Ingrid, Tidehag, Viktor, Rubenson-Wahlin, Rebecka, Strömmer, Lovisa, Westberg, Karin, Ängeby, Kristian, Djärv, Therese, Lundblad, Olof, Bartek, Jiri, Thelin, Eric Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438191/
https://www.ncbi.nlm.nih.gov/pubmed/36581962
http://dx.doi.org/10.1136/bmjopen-2021-060679
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author Fletcher‑Sandersjöö, Alexander
Tatter, Charles
Yang, Li
Pontén, Emeli
Boman, Magnus
Lassarén, Philipp
Forsberg, Sune
Grönlund, Ingrid
Tidehag, Viktor
Rubenson-Wahlin, Rebecka
Strömmer, Lovisa
Westberg, Karin
Ängeby, Kristian
Djärv, Therese
Lundblad, Olof
Bartek, Jiri
Thelin, Eric Peter
author_facet Fletcher‑Sandersjöö, Alexander
Tatter, Charles
Yang, Li
Pontén, Emeli
Boman, Magnus
Lassarén, Philipp
Forsberg, Sune
Grönlund, Ingrid
Tidehag, Viktor
Rubenson-Wahlin, Rebecka
Strömmer, Lovisa
Westberg, Karin
Ängeby, Kristian
Djärv, Therese
Lundblad, Olof
Bartek, Jiri
Thelin, Eric Peter
author_sort Fletcher‑Sandersjöö, Alexander
collection PubMed
description INTRODUCTION: Mild traumatic brain injury (mTBI) is one of the most common reasons for emergency department (ED) visits. A portion of patients with mTBI will develop an intracranial lesion that might require medical or surgical intervention. In these patients, swift diagnosis and management is paramount. Several guidelines have been developed to help direct patients with mTBI for head CT scanning, but they lack specificity, do not consider the interactions between risk factors and do not provide an individualised estimate of intracranial lesion risk. The aim of this study is to create a model that estimates individualised intracranial lesion risks in patients with mTBI who present to the ED. METHODS AND ANALYSIS: This will be a retrospective cohort study conducted at ED hospitals in Stockholm, Sweden. Eligible patients are adults (≥15 years) with mTBI who presented to the ED within 24 hours of injury and performed a CT scan. The primary outcome will be a traumatic lesion on head CT. The secondary outcomes will be any clinically significant lesion, defined as an intracranial finding that led to neurosurgical intervention, hospital admission ≥48 hours due to TBI or death due to TBI. Machine-learning models will be applied to create scores predicting the primary and secondary outcomes. An estimated 20 000 patients will be included. ETHICS AND DISSEMINATION: The study has been approved by the Swedish Ethical Review Authority (Dnr: 2020-05728). The research findings will be disseminated through peer-reviewed scientific publications and presentations at international conferences. TRIAL REGISTRATION NUMBER: NCT04995068.
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spelling pubmed-94381912022-09-14 Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study Fletcher‑Sandersjöö, Alexander Tatter, Charles Yang, Li Pontén, Emeli Boman, Magnus Lassarén, Philipp Forsberg, Sune Grönlund, Ingrid Tidehag, Viktor Rubenson-Wahlin, Rebecka Strömmer, Lovisa Westberg, Karin Ängeby, Kristian Djärv, Therese Lundblad, Olof Bartek, Jiri Thelin, Eric Peter BMJ Open Emergency Medicine INTRODUCTION: Mild traumatic brain injury (mTBI) is one of the most common reasons for emergency department (ED) visits. A portion of patients with mTBI will develop an intracranial lesion that might require medical or surgical intervention. In these patients, swift diagnosis and management is paramount. Several guidelines have been developed to help direct patients with mTBI for head CT scanning, but they lack specificity, do not consider the interactions between risk factors and do not provide an individualised estimate of intracranial lesion risk. The aim of this study is to create a model that estimates individualised intracranial lesion risks in patients with mTBI who present to the ED. METHODS AND ANALYSIS: This will be a retrospective cohort study conducted at ED hospitals in Stockholm, Sweden. Eligible patients are adults (≥15 years) with mTBI who presented to the ED within 24 hours of injury and performed a CT scan. The primary outcome will be a traumatic lesion on head CT. The secondary outcomes will be any clinically significant lesion, defined as an intracranial finding that led to neurosurgical intervention, hospital admission ≥48 hours due to TBI or death due to TBI. Machine-learning models will be applied to create scores predicting the primary and secondary outcomes. An estimated 20 000 patients will be included. ETHICS AND DISSEMINATION: The study has been approved by the Swedish Ethical Review Authority (Dnr: 2020-05728). The research findings will be disseminated through peer-reviewed scientific publications and presentations at international conferences. TRIAL REGISTRATION NUMBER: NCT04995068. BMJ Publishing Group 2022-09-01 /pmc/articles/PMC9438191/ /pubmed/36581962 http://dx.doi.org/10.1136/bmjopen-2021-060679 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Emergency Medicine
Fletcher‑Sandersjöö, Alexander
Tatter, Charles
Yang, Li
Pontén, Emeli
Boman, Magnus
Lassarén, Philipp
Forsberg, Sune
Grönlund, Ingrid
Tidehag, Viktor
Rubenson-Wahlin, Rebecka
Strömmer, Lovisa
Westberg, Karin
Ängeby, Kristian
Djärv, Therese
Lundblad, Olof
Bartek, Jiri
Thelin, Eric Peter
Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study
title Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study
title_full Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study
title_fullStr Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study
title_full_unstemmed Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study
title_short Stockholm score of lesion detection on computed tomography following mild traumatic brain injury (SELECT-TBI): study protocol for a multicentre, retrospective, observational cohort study
title_sort stockholm score of lesion detection on computed tomography following mild traumatic brain injury (select-tbi): study protocol for a multicentre, retrospective, observational cohort study
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438191/
https://www.ncbi.nlm.nih.gov/pubmed/36581962
http://dx.doi.org/10.1136/bmjopen-2021-060679
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