CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

BACKGROUND: Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs. Because the insulator protein CTCF is enriched at LAD borders, it was postulated that CTCF binding co...

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Detalles Bibliográficos
Autores principales: van Schaik, Tom, Liu, Ning Qing, Manzo, Stefano G., Peric-Hupkes, Daan, de Wit, Elzo, van Steensel, Bas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438259/
https://www.ncbi.nlm.nih.gov/pubmed/36050765
http://dx.doi.org/10.1186/s13059-022-02754-3

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