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FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications
The increasing prevalence of obesity worldwide is associated with an increased risk of various diseases, including multiple metabolic diseases, cardiovascular diseases, and malignant tumors. Fatty acid binding proteins (FABPs) are members of the adipokine family of multifunctional proteins that are...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438896/ https://www.ncbi.nlm.nih.gov/pubmed/36060264 http://dx.doi.org/10.3389/fmolb.2022.973955 |
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author | Liu, Shujie Wu, Dong Fan, Zhiyao Yang, Jian Li, Yongzheng Meng, Yufan Gao, Changhao Zhan, Hanxiang |
author_facet | Liu, Shujie Wu, Dong Fan, Zhiyao Yang, Jian Li, Yongzheng Meng, Yufan Gao, Changhao Zhan, Hanxiang |
author_sort | Liu, Shujie |
collection | PubMed |
description | The increasing prevalence of obesity worldwide is associated with an increased risk of various diseases, including multiple metabolic diseases, cardiovascular diseases, and malignant tumors. Fatty acid binding proteins (FABPs) are members of the adipokine family of multifunctional proteins that are related to fatty acid metabolism and are divided into 12 types according to their tissue origin. FABP4 is mainly secreted by adipocytes and macrophages. Under obesity, the synthesis of FABP4 increases, and the FABP4 content is higher not only in tissues but also in the blood, which promotes the occurrence and development of various cancers. Here, we comprehensively investigated obesity epidemiology and the biological mechanisms associated with the functions of FABP4 that may explain this effect. In this review, we explore the molecular mechanisms by which FABP4 promotes carcinoma development and the interaction between fat and cancer cells in obese circumstances here. This review leads us to understand how FABP4 signaling is involved in obesity-associated tumors, which could increase the potential for advancing novel therapeutic strategies and molecular targets for the systematic treatment of malignant tumors. |
format | Online Article Text |
id | pubmed-9438896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94388962022-09-03 FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications Liu, Shujie Wu, Dong Fan, Zhiyao Yang, Jian Li, Yongzheng Meng, Yufan Gao, Changhao Zhan, Hanxiang Front Mol Biosci Molecular Biosciences The increasing prevalence of obesity worldwide is associated with an increased risk of various diseases, including multiple metabolic diseases, cardiovascular diseases, and malignant tumors. Fatty acid binding proteins (FABPs) are members of the adipokine family of multifunctional proteins that are related to fatty acid metabolism and are divided into 12 types according to their tissue origin. FABP4 is mainly secreted by adipocytes and macrophages. Under obesity, the synthesis of FABP4 increases, and the FABP4 content is higher not only in tissues but also in the blood, which promotes the occurrence and development of various cancers. Here, we comprehensively investigated obesity epidemiology and the biological mechanisms associated with the functions of FABP4 that may explain this effect. In this review, we explore the molecular mechanisms by which FABP4 promotes carcinoma development and the interaction between fat and cancer cells in obese circumstances here. This review leads us to understand how FABP4 signaling is involved in obesity-associated tumors, which could increase the potential for advancing novel therapeutic strategies and molecular targets for the systematic treatment of malignant tumors. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9438896/ /pubmed/36060264 http://dx.doi.org/10.3389/fmolb.2022.973955 Text en Copyright © 2022 Liu, Wu, Fan, Yang, Li, Meng, Gao and Zhan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Liu, Shujie Wu, Dong Fan, Zhiyao Yang, Jian Li, Yongzheng Meng, Yufan Gao, Changhao Zhan, Hanxiang FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications |
title | FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications |
title_full | FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications |
title_fullStr | FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications |
title_full_unstemmed | FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications |
title_short | FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications |
title_sort | fabp4 in obesity-associated carcinogenesis: novel insights into mechanisms and therapeutic implications |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438896/ https://www.ncbi.nlm.nih.gov/pubmed/36060264 http://dx.doi.org/10.3389/fmolb.2022.973955 |
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