Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

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Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have optimized human small intestinal organoid (hSIO) culturing, constitutively generating all differentiated cell types while maintaining an active stem cell compartment. IL-22 does not promote the expansion of stem cells...

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Detalles Bibliográficos
Autores principales: He, Gui-Wei, Lin, Lin, DeMartino, Jeff, Zheng, Xuan, Staliarova, Nadzeya, Dayton, Talya, Begthel, Harry, van de Wetering, Willine J., Bodewes, Eduard, van Zon, Jeroen, Tans, Sander, Lopez-Iglesias, Carmen, Peters, Peter J., Wu, Wei, Kotlarz, Daniel, Klein, Christoph, Margaritis, Thanasis, Holstege, Frank, Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438971/
https://www.ncbi.nlm.nih.gov/pubmed/36002022
http://dx.doi.org/10.1016/j.stem.2022.08.002
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