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Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439201/ https://www.ncbi.nlm.nih.gov/pubmed/36054114 http://dx.doi.org/10.1371/journal.pone.0273876 |
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author | Yoshikawa, Nobuhisa Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yokoi, Akira Kajiyama, Hiroaki |
author_facet | Yoshikawa, Nobuhisa Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yokoi, Akira Kajiyama, Hiroaki |
author_sort | Yoshikawa, Nobuhisa |
collection | PubMed |
description | We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlation between clinicopathological characteristics and survival by performing univariate and multivariate analyses. The serum albumin value at diagnosis was used as an index of malnutrition. The median follow-up period was 16.4 months (range, 0.9–91.4 months). On Kaplan-Meier analysis, the 1- and 2-year overall survival (OS) rates for all patients were 61.6% and 48.6%, respectively. The optimal serum albumin for predicting 1-year survival was 3.3 g/dL, as determined by the receiver operating characteristic curve to maximize the area under the curve. The OS of the patients with albumin >3.3 g/dL (n = 28) was significantly better than that of the patients with albumin ≤3.3 g/dL (n = 15) (p = 0.004). The univariate and multivariate analyses revealed that pretreatment serum albumin and mode of primary treatment were significantly associated with survival in patients with stage IVB cervical cancer. Hypoalbuminemia was an unfavorable prognostic factor for patients with metastatic cervical cancer. |
format | Online Article Text |
id | pubmed-9439201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94392012022-09-03 Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer Yoshikawa, Nobuhisa Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yokoi, Akira Kajiyama, Hiroaki PLoS One Research Article We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlation between clinicopathological characteristics and survival by performing univariate and multivariate analyses. The serum albumin value at diagnosis was used as an index of malnutrition. The median follow-up period was 16.4 months (range, 0.9–91.4 months). On Kaplan-Meier analysis, the 1- and 2-year overall survival (OS) rates for all patients were 61.6% and 48.6%, respectively. The optimal serum albumin for predicting 1-year survival was 3.3 g/dL, as determined by the receiver operating characteristic curve to maximize the area under the curve. The OS of the patients with albumin >3.3 g/dL (n = 28) was significantly better than that of the patients with albumin ≤3.3 g/dL (n = 15) (p = 0.004). The univariate and multivariate analyses revealed that pretreatment serum albumin and mode of primary treatment were significantly associated with survival in patients with stage IVB cervical cancer. Hypoalbuminemia was an unfavorable prognostic factor for patients with metastatic cervical cancer. Public Library of Science 2022-09-02 /pmc/articles/PMC9439201/ /pubmed/36054114 http://dx.doi.org/10.1371/journal.pone.0273876 Text en © 2022 Yoshikawa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yoshikawa, Nobuhisa Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yokoi, Akira Kajiyama, Hiroaki Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer |
title | Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer |
title_full | Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer |
title_fullStr | Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer |
title_full_unstemmed | Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer |
title_short | Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer |
title_sort | hypoalbuminemia for the prediction of survival in patients with stage ivb cervical cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439201/ https://www.ncbi.nlm.nih.gov/pubmed/36054114 http://dx.doi.org/10.1371/journal.pone.0273876 |
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