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Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer

We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlat...

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Autores principales: Yoshikawa, Nobuhisa, Yoshihara, Masato, Tamauchi, Satoshi, Ikeda, Yoshiki, Yokoi, Akira, Kajiyama, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439201/
https://www.ncbi.nlm.nih.gov/pubmed/36054114
http://dx.doi.org/10.1371/journal.pone.0273876
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author Yoshikawa, Nobuhisa
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yokoi, Akira
Kajiyama, Hiroaki
author_facet Yoshikawa, Nobuhisa
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yokoi, Akira
Kajiyama, Hiroaki
author_sort Yoshikawa, Nobuhisa
collection PubMed
description We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlation between clinicopathological characteristics and survival by performing univariate and multivariate analyses. The serum albumin value at diagnosis was used as an index of malnutrition. The median follow-up period was 16.4 months (range, 0.9–91.4 months). On Kaplan-Meier analysis, the 1- and 2-year overall survival (OS) rates for all patients were 61.6% and 48.6%, respectively. The optimal serum albumin for predicting 1-year survival was 3.3 g/dL, as determined by the receiver operating characteristic curve to maximize the area under the curve. The OS of the patients with albumin >3.3 g/dL (n = 28) was significantly better than that of the patients with albumin ≤3.3 g/dL (n = 15) (p = 0.004). The univariate and multivariate analyses revealed that pretreatment serum albumin and mode of primary treatment were significantly associated with survival in patients with stage IVB cervical cancer. Hypoalbuminemia was an unfavorable prognostic factor for patients with metastatic cervical cancer.
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spelling pubmed-94392012022-09-03 Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer Yoshikawa, Nobuhisa Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yokoi, Akira Kajiyama, Hiroaki PLoS One Research Article We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlation between clinicopathological characteristics and survival by performing univariate and multivariate analyses. The serum albumin value at diagnosis was used as an index of malnutrition. The median follow-up period was 16.4 months (range, 0.9–91.4 months). On Kaplan-Meier analysis, the 1- and 2-year overall survival (OS) rates for all patients were 61.6% and 48.6%, respectively. The optimal serum albumin for predicting 1-year survival was 3.3 g/dL, as determined by the receiver operating characteristic curve to maximize the area under the curve. The OS of the patients with albumin >3.3 g/dL (n = 28) was significantly better than that of the patients with albumin ≤3.3 g/dL (n = 15) (p = 0.004). The univariate and multivariate analyses revealed that pretreatment serum albumin and mode of primary treatment were significantly associated with survival in patients with stage IVB cervical cancer. Hypoalbuminemia was an unfavorable prognostic factor for patients with metastatic cervical cancer. Public Library of Science 2022-09-02 /pmc/articles/PMC9439201/ /pubmed/36054114 http://dx.doi.org/10.1371/journal.pone.0273876 Text en © 2022 Yoshikawa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yoshikawa, Nobuhisa
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yokoi, Akira
Kajiyama, Hiroaki
Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
title Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
title_full Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
title_fullStr Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
title_full_unstemmed Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
title_short Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer
title_sort hypoalbuminemia for the prediction of survival in patients with stage ivb cervical cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439201/
https://www.ncbi.nlm.nih.gov/pubmed/36054114
http://dx.doi.org/10.1371/journal.pone.0273876
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