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Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players

Melatonin has been proved to have positive effects on cellular damage and metabolic regulation. The aim of the study was to determine the effect of melatonin supplementation during an intensive training period on physical performance decline, oxidative stress and cellular damage state. The investiga...

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Autores principales: Farjallah, Mohamed Amine, Ghattassi, Kais, Kamoun, Anis, Graja, Ahmed, Ben Mahmoud, Lobna, Driss, Tarak, Jamoussi, Kamel, Sahnoun, Zouheir, Souissi, Nizar, Zmijewski, Piotr, Hammouda, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439208/
https://www.ncbi.nlm.nih.gov/pubmed/36054089
http://dx.doi.org/10.1371/journal.pone.0273719
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author Farjallah, Mohamed Amine
Ghattassi, Kais
Kamoun, Anis
Graja, Ahmed
Ben Mahmoud, Lobna
Driss, Tarak
Jamoussi, Kamel
Sahnoun, Zouheir
Souissi, Nizar
Zmijewski, Piotr
Hammouda, Omar
author_facet Farjallah, Mohamed Amine
Ghattassi, Kais
Kamoun, Anis
Graja, Ahmed
Ben Mahmoud, Lobna
Driss, Tarak
Jamoussi, Kamel
Sahnoun, Zouheir
Souissi, Nizar
Zmijewski, Piotr
Hammouda, Omar
author_sort Farjallah, Mohamed Amine
collection PubMed
description Melatonin has been proved to have positive effects on cellular damage and metabolic regulation. The aim of the study was to determine the effect of melatonin supplementation during an intensive training period on physical performance decline, oxidative stress and cellular damage state. The investigation was conducted on 20 soccer players who participated in an exhaustive six-day training schedule associated with daily 5 mg oral melatonin or placebo ingestion. Resting blood samples and physical performance were measured before and after the training period. The mixed 2-way ANOVA (group x training camp) showed that compared to placebo, melatonin intake prevented an increase in advanced oxidation protein products (p>0.05) and increased the antioxidant enzyme activity (i.e., superoxide dismutase; p<0.001). In addition, melatonin prevented an increase of biomarkers of renal function (e.g., creatinine; p>0.05) and biomarkers of muscle (e.g., creatine kinase; p>0.05) and liver (e.g., gamma-glutamyltransferase; p>0.05) damage. Furthermore, melatonin alleviated the deterioration in physical performance (countermovement jump, five-jump test and 20-m sprint; p>0.05). In conclusion, the obtained data showed increased oxidative stress and renal, muscle and liver damage in professional soccer players during an exhaustive training schedule. Melatonin intake during the training period exerts beneficial effects on physical performance and protects tissues against the deleterious effects of reactive oxygen species and cellular damage.
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spelling pubmed-94392082022-09-03 Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players Farjallah, Mohamed Amine Ghattassi, Kais Kamoun, Anis Graja, Ahmed Ben Mahmoud, Lobna Driss, Tarak Jamoussi, Kamel Sahnoun, Zouheir Souissi, Nizar Zmijewski, Piotr Hammouda, Omar PLoS One Research Article Melatonin has been proved to have positive effects on cellular damage and metabolic regulation. The aim of the study was to determine the effect of melatonin supplementation during an intensive training period on physical performance decline, oxidative stress and cellular damage state. The investigation was conducted on 20 soccer players who participated in an exhaustive six-day training schedule associated with daily 5 mg oral melatonin or placebo ingestion. Resting blood samples and physical performance were measured before and after the training period. The mixed 2-way ANOVA (group x training camp) showed that compared to placebo, melatonin intake prevented an increase in advanced oxidation protein products (p>0.05) and increased the antioxidant enzyme activity (i.e., superoxide dismutase; p<0.001). In addition, melatonin prevented an increase of biomarkers of renal function (e.g., creatinine; p>0.05) and biomarkers of muscle (e.g., creatine kinase; p>0.05) and liver (e.g., gamma-glutamyltransferase; p>0.05) damage. Furthermore, melatonin alleviated the deterioration in physical performance (countermovement jump, five-jump test and 20-m sprint; p>0.05). In conclusion, the obtained data showed increased oxidative stress and renal, muscle and liver damage in professional soccer players during an exhaustive training schedule. Melatonin intake during the training period exerts beneficial effects on physical performance and protects tissues against the deleterious effects of reactive oxygen species and cellular damage. Public Library of Science 2022-09-02 /pmc/articles/PMC9439208/ /pubmed/36054089 http://dx.doi.org/10.1371/journal.pone.0273719 Text en © 2022 Farjallah et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Farjallah, Mohamed Amine
Ghattassi, Kais
Kamoun, Anis
Graja, Ahmed
Ben Mahmoud, Lobna
Driss, Tarak
Jamoussi, Kamel
Sahnoun, Zouheir
Souissi, Nizar
Zmijewski, Piotr
Hammouda, Omar
Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
title Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
title_full Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
title_fullStr Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
title_full_unstemmed Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
title_short Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
title_sort melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439208/
https://www.ncbi.nlm.nih.gov/pubmed/36054089
http://dx.doi.org/10.1371/journal.pone.0273719
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