Cargando…
Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies
INTRODUCTION: Approximately 80% of children, adolescents and young adults (CAYA) cancer patients are expected to fully recover and survive for five years or more. The reproductive health is a particular area of their concern. Evidence demonstrates that previous therapeutic treatments for cancer and...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439218/ https://www.ncbi.nlm.nih.gov/pubmed/36054199 http://dx.doi.org/10.1371/journal.pone.0273561 |
_version_ | 1784782004823261184 |
---|---|
author | Deng, Fang Gao, Xiuan Xu, Limian Li, Weijie Mei, Zubing Xie, Caijun |
author_facet | Deng, Fang Gao, Xiuan Xu, Limian Li, Weijie Mei, Zubing Xie, Caijun |
author_sort | Deng, Fang |
collection | PubMed |
description | INTRODUCTION: Approximately 80% of children, adolescents and young adults (CAYA) cancer patients are expected to fully recover and survive for five years or more. The reproductive health is a particular area of their concern. Evidence demonstrates that previous therapeutic treatments for cancer and comorbidities may have harmful effects on female fertility and delivery outcomes, which will significantly affect patient quality of life. However, these reports are heterogeneous. Therefore, the purpose of this study is to provide the up-to-date evidence on the risk of adverse obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer. METHODS AND ANALYSIS: This meta-analysis will be carried out and reported with adherence to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the Cochrane Handbook. We will search online databases including PubMed, Cochrane Library, and Embase from inception to August, 2022 to identify all relevant cohort studies examining the relationship between cancer and subsequent obstetric and perinatal outcomes. Data extraction from eligible studies will be conducted and crosschecked separately by two investigators using pre-tested standardized data extraction forms. Discrepancies will be resolved via a third investigator. Methodological quality assessment for each study will be conducted using the Newcastle–Ottawa scale (NOS) tool. We will apply the DerSimonian-Laird random-effects model to calculate the pooled estimates. Further sources of heterogeneity will be explored by performing subgroup analysis based on multiple study characteristics. Potential publication bias will be assessed by inspection of a funnel plot, Begg’s and Egger’s regression tests of funnel plot asymmetry. ETHICS AND DISSEMINATION: Ethical approval will not be required as all data used for this pooled analysis will be obtained from published cohort studies. The results of this study will be disseminated in a peer-reviewed journal and conference presentation. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/K6QBG. |
format | Online Article Text |
id | pubmed-9439218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94392182022-09-03 Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies Deng, Fang Gao, Xiuan Xu, Limian Li, Weijie Mei, Zubing Xie, Caijun PLoS One Study Protocol INTRODUCTION: Approximately 80% of children, adolescents and young adults (CAYA) cancer patients are expected to fully recover and survive for five years or more. The reproductive health is a particular area of their concern. Evidence demonstrates that previous therapeutic treatments for cancer and comorbidities may have harmful effects on female fertility and delivery outcomes, which will significantly affect patient quality of life. However, these reports are heterogeneous. Therefore, the purpose of this study is to provide the up-to-date evidence on the risk of adverse obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer. METHODS AND ANALYSIS: This meta-analysis will be carried out and reported with adherence to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the Cochrane Handbook. We will search online databases including PubMed, Cochrane Library, and Embase from inception to August, 2022 to identify all relevant cohort studies examining the relationship between cancer and subsequent obstetric and perinatal outcomes. Data extraction from eligible studies will be conducted and crosschecked separately by two investigators using pre-tested standardized data extraction forms. Discrepancies will be resolved via a third investigator. Methodological quality assessment for each study will be conducted using the Newcastle–Ottawa scale (NOS) tool. We will apply the DerSimonian-Laird random-effects model to calculate the pooled estimates. Further sources of heterogeneity will be explored by performing subgroup analysis based on multiple study characteristics. Potential publication bias will be assessed by inspection of a funnel plot, Begg’s and Egger’s regression tests of funnel plot asymmetry. ETHICS AND DISSEMINATION: Ethical approval will not be required as all data used for this pooled analysis will be obtained from published cohort studies. The results of this study will be disseminated in a peer-reviewed journal and conference presentation. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/K6QBG. Public Library of Science 2022-09-02 /pmc/articles/PMC9439218/ /pubmed/36054199 http://dx.doi.org/10.1371/journal.pone.0273561 Text en © 2022 Deng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Study Protocol Deng, Fang Gao, Xiuan Xu, Limian Li, Weijie Mei, Zubing Xie, Caijun Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies |
title | Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies |
title_full | Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies |
title_fullStr | Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies |
title_full_unstemmed | Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies |
title_short | Obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: Protocol of a meta-analysis of population-based cohort studies |
title_sort | obstetric and perinatal outcomes in female survivors of childhood or adolescent cancer: protocol of a meta-analysis of population-based cohort studies |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439218/ https://www.ncbi.nlm.nih.gov/pubmed/36054199 http://dx.doi.org/10.1371/journal.pone.0273561 |
work_keys_str_mv | AT dengfang obstetricandperinataloutcomesinfemalesurvivorsofchildhoodoradolescentcancerprotocolofametaanalysisofpopulationbasedcohortstudies AT gaoxiuan obstetricandperinataloutcomesinfemalesurvivorsofchildhoodoradolescentcancerprotocolofametaanalysisofpopulationbasedcohortstudies AT xulimian obstetricandperinataloutcomesinfemalesurvivorsofchildhoodoradolescentcancerprotocolofametaanalysisofpopulationbasedcohortstudies AT liweijie obstetricandperinataloutcomesinfemalesurvivorsofchildhoodoradolescentcancerprotocolofametaanalysisofpopulationbasedcohortstudies AT meizubing obstetricandperinataloutcomesinfemalesurvivorsofchildhoodoradolescentcancerprotocolofametaanalysisofpopulationbasedcohortstudies AT xiecaijun obstetricandperinataloutcomesinfemalesurvivorsofchildhoodoradolescentcancerprotocolofametaanalysisofpopulationbasedcohortstudies |