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The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure

During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while p...

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Autores principales: Li, Chan, Yue, Chen, Liu, Zhao-Chang, Gong, Jin, Wei, Xiao-Song, Yang, Heng, Gilmore, Campbell, Yu, Sheng-Bo, Hack, Gary D., Sui, Hong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439232/
https://www.ncbi.nlm.nih.gov/pubmed/36054096
http://dx.doi.org/10.1371/journal.pone.0273193
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author Li, Chan
Yue, Chen
Liu, Zhao-Chang
Gong, Jin
Wei, Xiao-Song
Yang, Heng
Gilmore, Campbell
Yu, Sheng-Bo
Hack, Gary D.
Sui, Hong-Jin
author_facet Li, Chan
Yue, Chen
Liu, Zhao-Chang
Gong, Jin
Wei, Xiao-Song
Yang, Heng
Gilmore, Campbell
Yu, Sheng-Bo
Hack, Gary D.
Sui, Hong-Jin
author_sort Li, Chan
collection PubMed
description During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics.
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spelling pubmed-94392322022-09-03 The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure Li, Chan Yue, Chen Liu, Zhao-Chang Gong, Jin Wei, Xiao-Song Yang, Heng Gilmore, Campbell Yu, Sheng-Bo Hack, Gary D. Sui, Hong-Jin PLoS One Research Article During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics. Public Library of Science 2022-09-02 /pmc/articles/PMC9439232/ /pubmed/36054096 http://dx.doi.org/10.1371/journal.pone.0273193 Text en © 2022 Li et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Chan
Yue, Chen
Liu, Zhao-Chang
Gong, Jin
Wei, Xiao-Song
Yang, Heng
Gilmore, Campbell
Yu, Sheng-Bo
Hack, Gary D.
Sui, Hong-Jin
The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
title The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
title_full The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
title_fullStr The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
title_full_unstemmed The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
title_short The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
title_sort relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439232/
https://www.ncbi.nlm.nih.gov/pubmed/36054096
http://dx.doi.org/10.1371/journal.pone.0273193
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