Cargando…
The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure
During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while p...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439232/ https://www.ncbi.nlm.nih.gov/pubmed/36054096 http://dx.doi.org/10.1371/journal.pone.0273193 |
_version_ | 1784782008548851712 |
---|---|
author | Li, Chan Yue, Chen Liu, Zhao-Chang Gong, Jin Wei, Xiao-Song Yang, Heng Gilmore, Campbell Yu, Sheng-Bo Hack, Gary D. Sui, Hong-Jin |
author_facet | Li, Chan Yue, Chen Liu, Zhao-Chang Gong, Jin Wei, Xiao-Song Yang, Heng Gilmore, Campbell Yu, Sheng-Bo Hack, Gary D. Sui, Hong-Jin |
author_sort | Li, Chan |
collection | PubMed |
description | During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics. |
format | Online Article Text |
id | pubmed-9439232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94392322022-09-03 The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure Li, Chan Yue, Chen Liu, Zhao-Chang Gong, Jin Wei, Xiao-Song Yang, Heng Gilmore, Campbell Yu, Sheng-Bo Hack, Gary D. Sui, Hong-Jin PLoS One Research Article During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics. Public Library of Science 2022-09-02 /pmc/articles/PMC9439232/ /pubmed/36054096 http://dx.doi.org/10.1371/journal.pone.0273193 Text en © 2022 Li et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Li, Chan Yue, Chen Liu, Zhao-Chang Gong, Jin Wei, Xiao-Song Yang, Heng Gilmore, Campbell Yu, Sheng-Bo Hack, Gary D. Sui, Hong-Jin The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
title | The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
title_full | The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
title_fullStr | The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
title_full_unstemmed | The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
title_short | The relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
title_sort | relationship between myodural bridges, hyperplasia of the suboccipital musculature, and intracranial pressure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439232/ https://www.ncbi.nlm.nih.gov/pubmed/36054096 http://dx.doi.org/10.1371/journal.pone.0273193 |
work_keys_str_mv | AT lichan therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT yuechen therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT liuzhaochang therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT gongjin therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT weixiaosong therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT yangheng therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT gilmorecampbell therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT yushengbo therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT hackgaryd therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT suihongjin therelationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT lichan relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT yuechen relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT liuzhaochang relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT gongjin relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT weixiaosong relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT yangheng relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT gilmorecampbell relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT yushengbo relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT hackgaryd relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure AT suihongjin relationshipbetweenmyoduralbridgeshyperplasiaofthesuboccipitalmusculatureandintracranialpressure |