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Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora

Melatonin is an indole-like neuroendocrine hormone. A large number of studies have shown that melatonin can improve production performance of ewes, but it is not clear in lambs. In this study, the growth and development of the 2-month-old lambs implanted with melatonin were monitored for 60 days. Th...

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Autores principales: Ma, Wenkui, Wu, Hao, Li, Guangdong, Yan, Laiqing, Wang, Likai, Zhao, Mengmeng, Guan, Shengyu, Xu, Shang, Guo, Xiaokai, Liu, Fenze, Ji, Pengyun, Wusiman, Abulizi, Liu, Guoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439620/
https://www.ncbi.nlm.nih.gov/pubmed/36060949
http://dx.doi.org/10.3389/fendo.2022.966120
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author Ma, Wenkui
Wu, Hao
Li, Guangdong
Yan, Laiqing
Wang, Likai
Zhao, Mengmeng
Guan, Shengyu
Xu, Shang
Guo, Xiaokai
Liu, Fenze
Ji, Pengyun
Wusiman, Abulizi
Liu, Guoshi
author_facet Ma, Wenkui
Wu, Hao
Li, Guangdong
Yan, Laiqing
Wang, Likai
Zhao, Mengmeng
Guan, Shengyu
Xu, Shang
Guo, Xiaokai
Liu, Fenze
Ji, Pengyun
Wusiman, Abulizi
Liu, Guoshi
author_sort Ma, Wenkui
collection PubMed
description Melatonin is an indole-like neuroendocrine hormone. A large number of studies have shown that melatonin can improve production performance of ewes, but it is not clear in lambs. In this study, the growth and development of the 2-month-old lambs implanted with melatonin were monitored for 60 days. The results showed that the growth rate of body weight and body skew length of lambs with melatonin treatment were significantly improved compared to the controls. The similar results were also observed in red blood cell count, hematocrit, red blood cell volume distribution width, the levels of growth hormone, testosterone, immunoglobulin A, immunoglobulin M and albumin. In addition, the cross sectional area of muscle fibers and adipose cells of lambs with melatonin implantation were also significantly increased compared to the controls (P<0.05). To further explore the potential mechanisms, the muscle and adipose tissue were selected for transcriptome sequencing. KEGG enrichment results showed that melatonin regulated the expression of genes related to apoptotic signaling pathway in muscle and adipocytes. Since the intestinal microbiota are involved in the nutritional balance and animal growth, the 16SrRNA sequencing related to the intestinal microbiota was also performed. The data indicated that the structural differences of fecal microflora mainly occur in the pathways of Cardiovascular disease, Excretory system and Signaling molecules and interaction. In brief, melatonin promotes the growth and development of lambs. The potential mechanisms may be that melatonin increased the growth hormone and testosterone mediated apoptosis signaling pathway and regulated intestinal microbial flora. Our results provide valuable information for melatonin to improve the production of sheep husbandry in the future.
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spelling pubmed-94396202022-09-03 Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora Ma, Wenkui Wu, Hao Li, Guangdong Yan, Laiqing Wang, Likai Zhao, Mengmeng Guan, Shengyu Xu, Shang Guo, Xiaokai Liu, Fenze Ji, Pengyun Wusiman, Abulizi Liu, Guoshi Front Endocrinol (Lausanne) Endocrinology Melatonin is an indole-like neuroendocrine hormone. A large number of studies have shown that melatonin can improve production performance of ewes, but it is not clear in lambs. In this study, the growth and development of the 2-month-old lambs implanted with melatonin were monitored for 60 days. The results showed that the growth rate of body weight and body skew length of lambs with melatonin treatment were significantly improved compared to the controls. The similar results were also observed in red blood cell count, hematocrit, red blood cell volume distribution width, the levels of growth hormone, testosterone, immunoglobulin A, immunoglobulin M and albumin. In addition, the cross sectional area of muscle fibers and adipose cells of lambs with melatonin implantation were also significantly increased compared to the controls (P<0.05). To further explore the potential mechanisms, the muscle and adipose tissue were selected for transcriptome sequencing. KEGG enrichment results showed that melatonin regulated the expression of genes related to apoptotic signaling pathway in muscle and adipocytes. Since the intestinal microbiota are involved in the nutritional balance and animal growth, the 16SrRNA sequencing related to the intestinal microbiota was also performed. The data indicated that the structural differences of fecal microflora mainly occur in the pathways of Cardiovascular disease, Excretory system and Signaling molecules and interaction. In brief, melatonin promotes the growth and development of lambs. The potential mechanisms may be that melatonin increased the growth hormone and testosterone mediated apoptosis signaling pathway and regulated intestinal microbial flora. Our results provide valuable information for melatonin to improve the production of sheep husbandry in the future. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9439620/ /pubmed/36060949 http://dx.doi.org/10.3389/fendo.2022.966120 Text en Copyright © 2022 Ma, Wu, Li, Yan, Wang, Zhao, Guan, Xu, Guo, Liu, Ji, Wusiman and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ma, Wenkui
Wu, Hao
Li, Guangdong
Yan, Laiqing
Wang, Likai
Zhao, Mengmeng
Guan, Shengyu
Xu, Shang
Guo, Xiaokai
Liu, Fenze
Ji, Pengyun
Wusiman, Abulizi
Liu, Guoshi
Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
title Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
title_full Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
title_fullStr Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
title_full_unstemmed Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
title_short Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
title_sort melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439620/
https://www.ncbi.nlm.nih.gov/pubmed/36060949
http://dx.doi.org/10.3389/fendo.2022.966120
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