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Variant Angina is Associated with Myocarditis
BACKGROUND: Vasospastic angina (VSA) is caused by severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor clinical outcomes, although nitrates and calcium blockers help improve patient symptoms because there is no understanding of the etiology and causal treatment....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439647/ https://www.ncbi.nlm.nih.gov/pubmed/36060213 http://dx.doi.org/10.2147/JIR.S378152 |
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author | Xu, Xin Wang, James Jiqi Zhao, Hu Miao, Kun Cui, Guanglin Zhang, Yuxuan Yang, Xiaoyun Wang, Luyun Wu, Junfang Wang, Dao Wen |
author_facet | Xu, Xin Wang, James Jiqi Zhao, Hu Miao, Kun Cui, Guanglin Zhang, Yuxuan Yang, Xiaoyun Wang, Luyun Wu, Junfang Wang, Dao Wen |
author_sort | Xu, Xin |
collection | PubMed |
description | BACKGROUND: Vasospastic angina (VSA) is caused by severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor clinical outcomes, although nitrates and calcium blockers help improve patient symptoms because there is no understanding of the etiology and causal treatment. The present study investigated whether VSA is associated with inflammation of the heart. PATIENTS AND METHODS: A total of 109 patients with VSA diagnosed by the presence of recurrent angina pectoris, typical electrocardiography, and coronary angiography were recruited, and 61 normal participants and 61 patients with acute myocardial infarction (AMI) and coronary artery stenosis were recruited as controls. The plasma levels of 24 cytokines were measured using a magnetic Luminex assay, and endothelin-1 and histamine levels tested using enzyme-linked immunosorbent assay and mass-spectrometry, respectively, for all participants. Furthermore, four patients with VSA underwent 18-fluorine fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). RESULTS: The plasma levels of interleukin (IL)-12p70, IL-13, PDL-1, IL-10, IL-6, IL-15, macrophage inflammatory protein (MIP)-1α, and MIP-1β in patients with VSA were significantly higher than those in both normal controls and patients with AMI (p<0.001) but did not differ between normal controls and patients with AMI. (18)F-FDG PET/CT showed that the left ventricle, coronary perivascular tissue volume, and coronary perivascular FDG uptake were significantly increased in all four patients. CONCLUSION: Our findings demonstrate that VSA patients have significantly elevated plasma cytokine levels and myocardial and pericoronary inflammation, suggesting that VSA is associated with myocarditis. This study provides novel insights into the etiology and treatment of VSA. |
format | Online Article Text |
id | pubmed-9439647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-94396472022-09-03 Variant Angina is Associated with Myocarditis Xu, Xin Wang, James Jiqi Zhao, Hu Miao, Kun Cui, Guanglin Zhang, Yuxuan Yang, Xiaoyun Wang, Luyun Wu, Junfang Wang, Dao Wen J Inflamm Res Clinical Trial Report BACKGROUND: Vasospastic angina (VSA) is caused by severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor clinical outcomes, although nitrates and calcium blockers help improve patient symptoms because there is no understanding of the etiology and causal treatment. The present study investigated whether VSA is associated with inflammation of the heart. PATIENTS AND METHODS: A total of 109 patients with VSA diagnosed by the presence of recurrent angina pectoris, typical electrocardiography, and coronary angiography were recruited, and 61 normal participants and 61 patients with acute myocardial infarction (AMI) and coronary artery stenosis were recruited as controls. The plasma levels of 24 cytokines were measured using a magnetic Luminex assay, and endothelin-1 and histamine levels tested using enzyme-linked immunosorbent assay and mass-spectrometry, respectively, for all participants. Furthermore, four patients with VSA underwent 18-fluorine fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). RESULTS: The plasma levels of interleukin (IL)-12p70, IL-13, PDL-1, IL-10, IL-6, IL-15, macrophage inflammatory protein (MIP)-1α, and MIP-1β in patients with VSA were significantly higher than those in both normal controls and patients with AMI (p<0.001) but did not differ between normal controls and patients with AMI. (18)F-FDG PET/CT showed that the left ventricle, coronary perivascular tissue volume, and coronary perivascular FDG uptake were significantly increased in all four patients. CONCLUSION: Our findings demonstrate that VSA patients have significantly elevated plasma cytokine levels and myocardial and pericoronary inflammation, suggesting that VSA is associated with myocarditis. This study provides novel insights into the etiology and treatment of VSA. Dove 2022-08-29 /pmc/articles/PMC9439647/ /pubmed/36060213 http://dx.doi.org/10.2147/JIR.S378152 Text en © 2022 Xu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Clinical Trial Report Xu, Xin Wang, James Jiqi Zhao, Hu Miao, Kun Cui, Guanglin Zhang, Yuxuan Yang, Xiaoyun Wang, Luyun Wu, Junfang Wang, Dao Wen Variant Angina is Associated with Myocarditis |
title | Variant Angina is Associated with Myocarditis |
title_full | Variant Angina is Associated with Myocarditis |
title_fullStr | Variant Angina is Associated with Myocarditis |
title_full_unstemmed | Variant Angina is Associated with Myocarditis |
title_short | Variant Angina is Associated with Myocarditis |
title_sort | variant angina is associated with myocarditis |
topic | Clinical Trial Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439647/ https://www.ncbi.nlm.nih.gov/pubmed/36060213 http://dx.doi.org/10.2147/JIR.S378152 |
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