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Variant Angina is Associated with Myocarditis

BACKGROUND: Vasospastic angina (VSA) is caused by severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor clinical outcomes, although nitrates and calcium blockers help improve patient symptoms because there is no understanding of the etiology and causal treatment....

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Autores principales: Xu, Xin, Wang, James Jiqi, Zhao, Hu, Miao, Kun, Cui, Guanglin, Zhang, Yuxuan, Yang, Xiaoyun, Wang, Luyun, Wu, Junfang, Wang, Dao Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439647/
https://www.ncbi.nlm.nih.gov/pubmed/36060213
http://dx.doi.org/10.2147/JIR.S378152
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author Xu, Xin
Wang, James Jiqi
Zhao, Hu
Miao, Kun
Cui, Guanglin
Zhang, Yuxuan
Yang, Xiaoyun
Wang, Luyun
Wu, Junfang
Wang, Dao Wen
author_facet Xu, Xin
Wang, James Jiqi
Zhao, Hu
Miao, Kun
Cui, Guanglin
Zhang, Yuxuan
Yang, Xiaoyun
Wang, Luyun
Wu, Junfang
Wang, Dao Wen
author_sort Xu, Xin
collection PubMed
description BACKGROUND: Vasospastic angina (VSA) is caused by severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor clinical outcomes, although nitrates and calcium blockers help improve patient symptoms because there is no understanding of the etiology and causal treatment. The present study investigated whether VSA is associated with inflammation of the heart. PATIENTS AND METHODS: A total of 109 patients with VSA diagnosed by the presence of recurrent angina pectoris, typical electrocardiography, and coronary angiography were recruited, and 61 normal participants and 61 patients with acute myocardial infarction (AMI) and coronary artery stenosis were recruited as controls. The plasma levels of 24 cytokines were measured using a magnetic Luminex assay, and endothelin-1 and histamine levels tested using enzyme-linked immunosorbent assay and mass-spectrometry, respectively, for all participants. Furthermore, four patients with VSA underwent 18-fluorine fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). RESULTS: The plasma levels of interleukin (IL)-12p70, IL-13, PDL-1, IL-10, IL-6, IL-15, macrophage inflammatory protein (MIP)-1α, and MIP-1β in patients with VSA were significantly higher than those in both normal controls and patients with AMI (p<0.001) but did not differ between normal controls and patients with AMI. (18)F-FDG PET/CT showed that the left ventricle, coronary perivascular tissue volume, and coronary perivascular FDG uptake were significantly increased in all four patients. CONCLUSION: Our findings demonstrate that VSA patients have significantly elevated plasma cytokine levels and myocardial and pericoronary inflammation, suggesting that VSA is associated with myocarditis. This study provides novel insights into the etiology and treatment of VSA.
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spelling pubmed-94396472022-09-03 Variant Angina is Associated with Myocarditis Xu, Xin Wang, James Jiqi Zhao, Hu Miao, Kun Cui, Guanglin Zhang, Yuxuan Yang, Xiaoyun Wang, Luyun Wu, Junfang Wang, Dao Wen J Inflamm Res Clinical Trial Report BACKGROUND: Vasospastic angina (VSA) is caused by severe diffuse or segmental coronary artery spasms. Patients with variant angina have poor clinical outcomes, although nitrates and calcium blockers help improve patient symptoms because there is no understanding of the etiology and causal treatment. The present study investigated whether VSA is associated with inflammation of the heart. PATIENTS AND METHODS: A total of 109 patients with VSA diagnosed by the presence of recurrent angina pectoris, typical electrocardiography, and coronary angiography were recruited, and 61 normal participants and 61 patients with acute myocardial infarction (AMI) and coronary artery stenosis were recruited as controls. The plasma levels of 24 cytokines were measured using a magnetic Luminex assay, and endothelin-1 and histamine levels tested using enzyme-linked immunosorbent assay and mass-spectrometry, respectively, for all participants. Furthermore, four patients with VSA underwent 18-fluorine fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). RESULTS: The plasma levels of interleukin (IL)-12p70, IL-13, PDL-1, IL-10, IL-6, IL-15, macrophage inflammatory protein (MIP)-1α, and MIP-1β in patients with VSA were significantly higher than those in both normal controls and patients with AMI (p<0.001) but did not differ between normal controls and patients with AMI. (18)F-FDG PET/CT showed that the left ventricle, coronary perivascular tissue volume, and coronary perivascular FDG uptake were significantly increased in all four patients. CONCLUSION: Our findings demonstrate that VSA patients have significantly elevated plasma cytokine levels and myocardial and pericoronary inflammation, suggesting that VSA is associated with myocarditis. This study provides novel insights into the etiology and treatment of VSA. Dove 2022-08-29 /pmc/articles/PMC9439647/ /pubmed/36060213 http://dx.doi.org/10.2147/JIR.S378152 Text en © 2022 Xu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Clinical Trial Report
Xu, Xin
Wang, James Jiqi
Zhao, Hu
Miao, Kun
Cui, Guanglin
Zhang, Yuxuan
Yang, Xiaoyun
Wang, Luyun
Wu, Junfang
Wang, Dao Wen
Variant Angina is Associated with Myocarditis
title Variant Angina is Associated with Myocarditis
title_full Variant Angina is Associated with Myocarditis
title_fullStr Variant Angina is Associated with Myocarditis
title_full_unstemmed Variant Angina is Associated with Myocarditis
title_short Variant Angina is Associated with Myocarditis
title_sort variant angina is associated with myocarditis
topic Clinical Trial Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439647/
https://www.ncbi.nlm.nih.gov/pubmed/36060213
http://dx.doi.org/10.2147/JIR.S378152
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