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Diagnosis and treatment of tuberculosis in adults with HIV

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), continues to pose a major public health problem and is the leading cause of mortality in people infected with human immunodeficiency virus (HIV). HIV infection greatly increases the risk of developing TB even before CD4+ T-cell co...

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Autores principales: Yang, Qiaoli, Han, Jinjin, Shen, Jingjing, Peng, Xinsen, Zhou, Lurong, Yin, Xuejing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439776/
https://www.ncbi.nlm.nih.gov/pubmed/36107594
http://dx.doi.org/10.1097/MD.0000000000030405
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author Yang, Qiaoli
Han, Jinjin
Shen, Jingjing
Peng, Xinsen
Zhou, Lurong
Yin, Xuejing
author_facet Yang, Qiaoli
Han, Jinjin
Shen, Jingjing
Peng, Xinsen
Zhou, Lurong
Yin, Xuejing
author_sort Yang, Qiaoli
collection PubMed
description Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), continues to pose a major public health problem and is the leading cause of mortality in people infected with human immunodeficiency virus (HIV). HIV infection greatly increases the risk of developing TB even before CD4+ T-cell counts decrease. Co-infection provides reciprocal advantages to both pathogens and leads to acceleration of both diseases. In HIV-coinfected persons, the diagnosis and treatment of tuberculosis are particularly challenging. Intensifying integration of HIV and tuberculosis control programmes has an impact on reducing diagnostic delays, increasing early case detection, providing prompt treatment onset, and ultimately reducing transmission. In this Review, we describe our current understanding of how these two pathogens interact with each other, new sensitive rapid assays for TB, several new prevention methods, new drugs and regimens.
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spelling pubmed-94397762022-09-06 Diagnosis and treatment of tuberculosis in adults with HIV Yang, Qiaoli Han, Jinjin Shen, Jingjing Peng, Xinsen Zhou, Lurong Yin, Xuejing Medicine (Baltimore) Research Article Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), continues to pose a major public health problem and is the leading cause of mortality in people infected with human immunodeficiency virus (HIV). HIV infection greatly increases the risk of developing TB even before CD4+ T-cell counts decrease. Co-infection provides reciprocal advantages to both pathogens and leads to acceleration of both diseases. In HIV-coinfected persons, the diagnosis and treatment of tuberculosis are particularly challenging. Intensifying integration of HIV and tuberculosis control programmes has an impact on reducing diagnostic delays, increasing early case detection, providing prompt treatment onset, and ultimately reducing transmission. In this Review, we describe our current understanding of how these two pathogens interact with each other, new sensitive rapid assays for TB, several new prevention methods, new drugs and regimens. Lippincott Williams & Wilkins 2022-09-02 /pmc/articles/PMC9439776/ /pubmed/36107594 http://dx.doi.org/10.1097/MD.0000000000030405 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Qiaoli
Han, Jinjin
Shen, Jingjing
Peng, Xinsen
Zhou, Lurong
Yin, Xuejing
Diagnosis and treatment of tuberculosis in adults with HIV
title Diagnosis and treatment of tuberculosis in adults with HIV
title_full Diagnosis and treatment of tuberculosis in adults with HIV
title_fullStr Diagnosis and treatment of tuberculosis in adults with HIV
title_full_unstemmed Diagnosis and treatment of tuberculosis in adults with HIV
title_short Diagnosis and treatment of tuberculosis in adults with HIV
title_sort diagnosis and treatment of tuberculosis in adults with hiv
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439776/
https://www.ncbi.nlm.nih.gov/pubmed/36107594
http://dx.doi.org/10.1097/MD.0000000000030405
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