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Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis
There is no study analyzing and evaluating the prognostic role of thrombocytosis in Asian patients with colorectal cancer (CRC). METHODS: A systematic search of articles (PubMed, Embase, and the Cochrane Library) was performed to identify studies using the terms Platelet count, Thrombocytosis, Throm...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439792/ https://www.ncbi.nlm.nih.gov/pubmed/36107503 http://dx.doi.org/10.1097/MD.0000000000030275 |
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author | Xia, Shijun Wu, Wenjiang Yu, Linchong Ma, Lijuan Chen, Shiwei Wang, Hao |
author_facet | Xia, Shijun Wu, Wenjiang Yu, Linchong Ma, Lijuan Chen, Shiwei Wang, Hao |
author_sort | Xia, Shijun |
collection | PubMed |
description | There is no study analyzing and evaluating the prognostic role of thrombocytosis in Asian patients with colorectal cancer (CRC). METHODS: A systematic search of articles (PubMed, Embase, and the Cochrane Library) was performed to identify studies using the terms Platelet count, Thrombocytosis, Thrombocytoses, Thrombocythemia or Thrombocythemias with colon, colonic, rectal, rectum, colorectal and prognostic, prognosis, survival or outcome. RESULTS: Thirteen eligible studies with 3964 patients were included. Thrombocytosis was associated with a poorer overall survival (HR of 1.88 [95% CI: 1.24–2.85; P = .003] with univariate analyses, HR of 2.07 [95% CI: 1.2–3.56; P = .008] with multivariate analyses), disease-free survival (HR of 2.58 [95% CI: 1.87–3.57; P < .00001] with multivariate analyses) and cancer specific survival (HR of 2.55 [95% CI: 1.68–3.85; P < .00001]) in Asian patients with CRC. Thrombocytosis had a significant association with female gender, tumor location in the colon, higher pathological T-stage, pathological positive N-stage, but not with lymphatic involvement and venous involvement. CONCLUSION: The present meta-analysis demonstrates that thrombocytosis is a potentially useful tool for predicting poor survival in Asian patients with CRC, especially for overall survival. |
format | Online Article Text |
id | pubmed-9439792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-94397922022-09-06 Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis Xia, Shijun Wu, Wenjiang Yu, Linchong Ma, Lijuan Chen, Shiwei Wang, Hao Medicine (Baltimore) Research Article There is no study analyzing and evaluating the prognostic role of thrombocytosis in Asian patients with colorectal cancer (CRC). METHODS: A systematic search of articles (PubMed, Embase, and the Cochrane Library) was performed to identify studies using the terms Platelet count, Thrombocytosis, Thrombocytoses, Thrombocythemia or Thrombocythemias with colon, colonic, rectal, rectum, colorectal and prognostic, prognosis, survival or outcome. RESULTS: Thirteen eligible studies with 3964 patients were included. Thrombocytosis was associated with a poorer overall survival (HR of 1.88 [95% CI: 1.24–2.85; P = .003] with univariate analyses, HR of 2.07 [95% CI: 1.2–3.56; P = .008] with multivariate analyses), disease-free survival (HR of 2.58 [95% CI: 1.87–3.57; P < .00001] with multivariate analyses) and cancer specific survival (HR of 2.55 [95% CI: 1.68–3.85; P < .00001]) in Asian patients with CRC. Thrombocytosis had a significant association with female gender, tumor location in the colon, higher pathological T-stage, pathological positive N-stage, but not with lymphatic involvement and venous involvement. CONCLUSION: The present meta-analysis demonstrates that thrombocytosis is a potentially useful tool for predicting poor survival in Asian patients with CRC, especially for overall survival. Lippincott Williams & Wilkins 2022-09-02 /pmc/articles/PMC9439792/ /pubmed/36107503 http://dx.doi.org/10.1097/MD.0000000000030275 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Xia, Shijun Wu, Wenjiang Yu, Linchong Ma, Lijuan Chen, Shiwei Wang, Hao Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis |
title | Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis |
title_full | Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis |
title_fullStr | Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis |
title_full_unstemmed | Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis |
title_short | Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis |
title_sort | thrombocytosis predicts poor prognosis of asian patients with colorectal cancer: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439792/ https://www.ncbi.nlm.nih.gov/pubmed/36107503 http://dx.doi.org/10.1097/MD.0000000000030275 |
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