The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling

Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death. A major challenge is to develop an effective treatment for COVID-19. NF-κB is a major player in innate immunity...

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Detalles Bibliográficos
Autores principales: Laplantine, Emmanuel, Chable-Bessia, Christine, Oudin, Anne, Swain, Jitendryia, Soria, Adèle, Merida, Peggy, Gourdelier, Manon, Mestiri, Sarra, Besseghe, Indira, Bremaud, Erwan, Neyret, Aymeric, Lyonnais, Sebastien, Favard, Cyril, Benaroch, Philippe, Hubert, Mathieu, Schwartz, Olivier, Guerin, Maryse, Danckaert, Anne, Del Nery, Elaine, Muriaux, Delphine, Weil, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439859/
https://www.ncbi.nlm.nih.gov/pubmed/36093378
http://dx.doi.org/10.1016/j.isci.2022.105066

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