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An Overview of DNA Methylation Indicators for the Course of Oral Precancer
DNA methylation is a physiologically epigenetic alteration that happens when a methyl group is introduced to a CpG dinucleotide in the gene-regulating sequence of DNA. However, the majority of oral cancers have a well-defined precancerous stage; there are few clinical and morphological parameters fo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439927/ https://www.ncbi.nlm.nih.gov/pubmed/36060560 http://dx.doi.org/10.1155/2022/6468773 |
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author | Wang, Wenjing Li, Wei Zhang, Hongyi |
author_facet | Wang, Wenjing Li, Wei Zhang, Hongyi |
author_sort | Wang, Wenjing |
collection | PubMed |
description | DNA methylation is a physiologically epigenetic alteration that happens when a methyl group is introduced to a CpG dinucleotide in the gene-regulating sequence of DNA. However, the majority of oral cancers have a well-defined precancerous stage; there are few clinical and morphological parameters for detecting and signalling the progression of precancerous to malignant tumours. DNA methylation forms are dynamic and reversible, allowing them to adjust to environmental or therapeutic changes. We did an extensive investigation to compile the data supporting aberrant DNA methylation forms as a possible biomarker for prediction. According to two longitudinal studies, p16 hypermethylation was considerably higher in precancerous lesions that progressed to cancer than in lesions that shrank. Most of the studies examined for this study were tiny cross-sectional research with scant validation and inadequately specified control groups. Existing evidence suggests that DNA methylation sequences can be relevant as a diagnostic biomarker for OPS development; however, sample size and research design restrictions make it difficult to draw definitive conclusions. Strong studies, including extensive epigenome-wide methylation scans of OPS with longitudinal monitoring, are necessary in this study in order to corroborate the recently discovered signals and discover new risk loci and disease progression molecular pathways. |
format | Online Article Text |
id | pubmed-9439927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94399272022-09-03 An Overview of DNA Methylation Indicators for the Course of Oral Precancer Wang, Wenjing Li, Wei Zhang, Hongyi Appl Bionics Biomech Review Article DNA methylation is a physiologically epigenetic alteration that happens when a methyl group is introduced to a CpG dinucleotide in the gene-regulating sequence of DNA. However, the majority of oral cancers have a well-defined precancerous stage; there are few clinical and morphological parameters for detecting and signalling the progression of precancerous to malignant tumours. DNA methylation forms are dynamic and reversible, allowing them to adjust to environmental or therapeutic changes. We did an extensive investigation to compile the data supporting aberrant DNA methylation forms as a possible biomarker for prediction. According to two longitudinal studies, p16 hypermethylation was considerably higher in precancerous lesions that progressed to cancer than in lesions that shrank. Most of the studies examined for this study were tiny cross-sectional research with scant validation and inadequately specified control groups. Existing evidence suggests that DNA methylation sequences can be relevant as a diagnostic biomarker for OPS development; however, sample size and research design restrictions make it difficult to draw definitive conclusions. Strong studies, including extensive epigenome-wide methylation scans of OPS with longitudinal monitoring, are necessary in this study in order to corroborate the recently discovered signals and discover new risk loci and disease progression molecular pathways. Hindawi 2022-08-26 /pmc/articles/PMC9439927/ /pubmed/36060560 http://dx.doi.org/10.1155/2022/6468773 Text en Copyright © 2022 Wenjing Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Wenjing Li, Wei Zhang, Hongyi An Overview of DNA Methylation Indicators for the Course of Oral Precancer |
title | An Overview of DNA Methylation Indicators for the Course of Oral Precancer |
title_full | An Overview of DNA Methylation Indicators for the Course of Oral Precancer |
title_fullStr | An Overview of DNA Methylation Indicators for the Course of Oral Precancer |
title_full_unstemmed | An Overview of DNA Methylation Indicators for the Course of Oral Precancer |
title_short | An Overview of DNA Methylation Indicators for the Course of Oral Precancer |
title_sort | overview of dna methylation indicators for the course of oral precancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439927/ https://www.ncbi.nlm.nih.gov/pubmed/36060560 http://dx.doi.org/10.1155/2022/6468773 |
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