Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose

BACKGROUND AND OBJECTIVE: Women with postpartum depression (PPD) may expose their infants to antidepressants via breast milk. Brexanolone is the only FDA-approved antidepressant specifically indicated for the treatment of PPD. This open-label, phase Ib study of healthy lactating volunteers assessed...

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Detalles Bibliográficos
Autores principales: Wald, Jeffrey, Henningsson, Anja, Hanze, Eva, Hoffmann, Ethan, Li, Haihong, Colquhoun, Helen, Deligiannidis, Kristina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439988/
https://www.ncbi.nlm.nih.gov/pubmed/35869362
http://dx.doi.org/10.1007/s40262-022-01155-w

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