IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation

Reactive astrogliosis usually bears some properties of neural progenitors. How injury triggers astrocyte dedifferentiation remains largely unclear. Here, we report that ischemia induces rapid up-regulation of Wnt2 protein in apoptotic neurons and activation of canonical Wnt signaling in reactive ast...

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Detalles Bibliográficos
Autores principales: Fan, Hong, Yang, Jialei, Zhang, Kun, Xing, Junling, Guo, Baolin, Mao, Honghui, Wang, Wenting, Hu, Yingzhou, Lin, Wei, Huang, Ying, Ding, Jian, Yu, Caiyong, Fu, Fanfan, Sun, Li, Wu, Jing, Zhao, Youyi, Deng, Wenbin, Zhou, Chengji, Qiu, Mengsheng, Wu, Shengxi, Ding, Yu-Qiang, Wang, Yazhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440034/
https://www.ncbi.nlm.nih.gov/pubmed/36056026
http://dx.doi.org/10.1038/s41536-022-00248-1

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