Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43

TAR DNA-binding protein 43 kDa (TDP-43), a nuclear protein, plays an important role in the molecular pathogenesis of amyotrophic lateral sclerosis (ALS). The long-disordered C-terminal region (CTR) of TDP-43 is known to be aggregation-prone and a hotspot for ALS mutations, so elucidation of the phys...

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Detalles Bibliográficos
Autores principales: Sato, Toshiya, Oda, Kanako, Sakai, Seiko, Kato, Rika, Yamamori, Saori, Itakura, Makoto, Kodera, Yoshio, Nishizawa, Masatoyo, Sasaoka, Toshikuni, Onodera, Osamu, Yokoyama, Minesuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440050/
https://www.ncbi.nlm.nih.gov/pubmed/36056157
http://dx.doi.org/10.1038/s41598-022-19153-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440050/
https://www.ncbi.nlm.nih.gov/pubmed/36056157
http://dx.doi.org/10.1038/s41598-022-19153-0

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