Lithium produces bi-directionally regulation of mood disturbance, acts synergistically with anti-depressive/-manic agents, and did not deteriorate the cognitive impairment in murine model of bipolar disorder

Lithium (Li) is a well-established mood disorder treatment and may be neuroprotective. Bi-directional regulation (i.e. affecting manic symptoms and depressive symptoms) by Li has not been demonstrated. This study explored: (1) bidirectional regulation by Li in murine models of depression, mania, and...

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Detalles Bibliográficos
Autores principales: Zhuo, Chuanjun, Zhou, Chunhua, Tian, Hongjun, Li, Qianchen, Chen, Jiayue, Yang, Lei, Zhang, Qiuyu, Li, Ranli, Ma, Xiaoyan, Cai, Ziyao, Chen, Guangdong, Xu, Yong, Song, Xueqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440114/
https://www.ncbi.nlm.nih.gov/pubmed/36055984
http://dx.doi.org/10.1038/s41398-022-02087-6

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