Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation

CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing. Here we create a transgenic mouse model, to enable direct m...

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Detalles Bibliográficos
Autores principales: Zhou, Dingxi, Borsa, Mariana, Puleston, Daniel J., Zellner, Susanne, Capera, Jesusa, Sanderson, Sharon, Schifferer, Martina, Hester, Svenja S., Ge, Xin, Fischer, Roman, Jostins, Luke, Behrends, Christian, Alsaleh, Ghada, Simon, Anna Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440129/
https://www.ncbi.nlm.nih.gov/pubmed/36055998
http://dx.doi.org/10.1038/s41467-022-32718-x

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