Rise of the human-mouse chimeric brain models

Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand huma...

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Detalles Bibliográficos
Autores principales: Jiang, Peng, Alam, Mahabub Maraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440171/
https://www.ncbi.nlm.nih.gov/pubmed/36056167
http://dx.doi.org/10.1186/s13619-022-00135-6
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author Jiang, Peng
Alam, Mahabub Maraj
author_facet Jiang, Peng
Alam, Mahabub Maraj
author_sort Jiang, Peng
collection PubMed
description Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.
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spelling pubmed-94401712022-09-16 Rise of the human-mouse chimeric brain models Jiang, Peng Alam, Mahabub Maraj Cell Regen Opinion Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders. Springer Nature Singapore 2022-09-03 /pmc/articles/PMC9440171/ /pubmed/36056167 http://dx.doi.org/10.1186/s13619-022-00135-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Opinion
Jiang, Peng
Alam, Mahabub Maraj
Rise of the human-mouse chimeric brain models
title Rise of the human-mouse chimeric brain models
title_full Rise of the human-mouse chimeric brain models
title_fullStr Rise of the human-mouse chimeric brain models
title_full_unstemmed Rise of the human-mouse chimeric brain models
title_short Rise of the human-mouse chimeric brain models
title_sort rise of the human-mouse chimeric brain models
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440171/
https://www.ncbi.nlm.nih.gov/pubmed/36056167
http://dx.doi.org/10.1186/s13619-022-00135-6
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