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The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method

Evidence suggests that β-secretase (BACE1), which cleaves Amyloid Precursor Protein (APP) to form sAPPβ and amyloid-β, is elevated in Alzheimer's disease (AD) brains and biofluids and, thus, BACE1 is a therapeutic target for this devastating disease. The direct product of BACE1 cleavage of APP,...

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Detalles Bibliográficos
Autores principales:	Dobrowolska Zakaria, Justyna A., Bateman, Randall J., Lysakowska, Monika, Khatri, Ammaarah, Jean-Gilles, Dinorah, Kennedy, Matthew E., Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440206/ https://www.ncbi.nlm.nih.gov/pubmed/36056033 http://dx.doi.org/10.1038/s41598-022-18869-3

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