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Nintedanib induces senolytic effect via STAT3 inhibition

Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even for reversing aging. We found that nintedanib, a tyrosine kinase inhibitor, selectively induced the death of primary human dermal fibroblasts undergoing...

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Detalles Bibliográficos
Autores principales:	Cho, Hyun-Ji, Hwang, Jeong-A, Yang, Eun Jae, Kim, Eok-Cheon, Kim, Jae-Ryong, Kim, Sung Young, Kim, Young Zoon, Park, Sang Chul, Lee, Young-Sam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440251/ https://www.ncbi.nlm.nih.gov/pubmed/36055997 http://dx.doi.org/10.1038/s41419-022-05207-8

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