Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7

Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is upregulated in the plasma membrane of fibrotic hepatocytes. Hepatocellular expression of PROM1 was also demonstrated in mice (Prom1(...

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Detalles Bibliográficos
Autores principales: Lee, Hyun, Yu, Dong-Min, Bahn, Myeong-Suk, Kwon, Young-Jae, Um, Min Jee, Yoon, Seo Yeon, Kim, Ki-Tae, Lee, Myoung-Woo, Jo, Sung-Je, Lee, Sungsoo, Koo, Seung-Hoi, Jung, Ki Hoon, Lee, Jae-Seon, Ko, Young-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440255/
https://www.ncbi.nlm.nih.gov/pubmed/36038590
http://dx.doi.org/10.1038/s12276-022-00831-y

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