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Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440277/ https://www.ncbi.nlm.nih.gov/pubmed/36065447 http://dx.doi.org/10.3389/fimmu.2022.952868 |
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author | Akanuma, Haruna Iizuka, Takahiro Abe, Dan Yoshida, Kenji Matsuda, Nozomu Sugimoto, Kotaro Hashimoto, Yuko Kanai, Kazuaki |
author_facet | Akanuma, Haruna Iizuka, Takahiro Abe, Dan Yoshida, Kenji Matsuda, Nozomu Sugimoto, Kotaro Hashimoto, Yuko Kanai, Kazuaki |
author_sort | Akanuma, Haruna |
collection | PubMed |
description | Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild inflammatory infiltration. We report a patient of small cell lung cancer (SCLC)-related paraneoplastic encephalitis with NMDAR antibodies, a cytotoxic T-cell-mediated pathology of the brain, and a rapid clinical course. This case highlights that the neuropathological diversity of NMDAR encephalitis may be even broader than previously thought and that NMDAR antibodies may also be found in various pathological conditions with a vigorous immune response. |
format | Online Article Text |
id | pubmed-9440277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94402772022-09-04 Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report Akanuma, Haruna Iizuka, Takahiro Abe, Dan Yoshida, Kenji Matsuda, Nozomu Sugimoto, Kotaro Hashimoto, Yuko Kanai, Kazuaki Front Immunol Immunology Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild inflammatory infiltration. We report a patient of small cell lung cancer (SCLC)-related paraneoplastic encephalitis with NMDAR antibodies, a cytotoxic T-cell-mediated pathology of the brain, and a rapid clinical course. This case highlights that the neuropathological diversity of NMDAR encephalitis may be even broader than previously thought and that NMDAR antibodies may also be found in various pathological conditions with a vigorous immune response. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9440277/ /pubmed/36065447 http://dx.doi.org/10.3389/fimmu.2022.952868 Text en Copyright © 2022 Akanuma, Iizuka, Abe, Yoshida, Matsuda, Sugimoto, Hashimoto and Kanai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attr0ibution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Akanuma, Haruna Iizuka, Takahiro Abe, Dan Yoshida, Kenji Matsuda, Nozomu Sugimoto, Kotaro Hashimoto, Yuko Kanai, Kazuaki Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report |
title | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report |
title_full | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report |
title_fullStr | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report |
title_full_unstemmed | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report |
title_short | Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report |
title_sort | paraneoplastic anti-n-methyl-d-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic t-cell-mediated pathology: case report |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440277/ https://www.ncbi.nlm.nih.gov/pubmed/36065447 http://dx.doi.org/10.3389/fimmu.2022.952868 |
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