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Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report

Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild...

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Autores principales: Akanuma, Haruna, Iizuka, Takahiro, Abe, Dan, Yoshida, Kenji, Matsuda, Nozomu, Sugimoto, Kotaro, Hashimoto, Yuko, Kanai, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440277/
https://www.ncbi.nlm.nih.gov/pubmed/36065447
http://dx.doi.org/10.3389/fimmu.2022.952868
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author Akanuma, Haruna
Iizuka, Takahiro
Abe, Dan
Yoshida, Kenji
Matsuda, Nozomu
Sugimoto, Kotaro
Hashimoto, Yuko
Kanai, Kazuaki
author_facet Akanuma, Haruna
Iizuka, Takahiro
Abe, Dan
Yoshida, Kenji
Matsuda, Nozomu
Sugimoto, Kotaro
Hashimoto, Yuko
Kanai, Kazuaki
author_sort Akanuma, Haruna
collection PubMed
description Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild inflammatory infiltration. We report a patient of small cell lung cancer (SCLC)-related paraneoplastic encephalitis with NMDAR antibodies, a cytotoxic T-cell-mediated pathology of the brain, and a rapid clinical course. This case highlights that the neuropathological diversity of NMDAR encephalitis may be even broader than previously thought and that NMDAR antibodies may also be found in various pathological conditions with a vigorous immune response.
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spelling pubmed-94402772022-09-04 Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report Akanuma, Haruna Iizuka, Takahiro Abe, Dan Yoshida, Kenji Matsuda, Nozomu Sugimoto, Kotaro Hashimoto, Yuko Kanai, Kazuaki Front Immunol Immunology Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild inflammatory infiltration. We report a patient of small cell lung cancer (SCLC)-related paraneoplastic encephalitis with NMDAR antibodies, a cytotoxic T-cell-mediated pathology of the brain, and a rapid clinical course. This case highlights that the neuropathological diversity of NMDAR encephalitis may be even broader than previously thought and that NMDAR antibodies may also be found in various pathological conditions with a vigorous immune response. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9440277/ /pubmed/36065447 http://dx.doi.org/10.3389/fimmu.2022.952868 Text en Copyright © 2022 Akanuma, Iizuka, Abe, Yoshida, Matsuda, Sugimoto, Hashimoto and Kanai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attr0ibution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Akanuma, Haruna
Iizuka, Takahiro
Abe, Dan
Yoshida, Kenji
Matsuda, Nozomu
Sugimoto, Kotaro
Hashimoto, Yuko
Kanai, Kazuaki
Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
title Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
title_full Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
title_fullStr Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
title_full_unstemmed Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
title_short Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report
title_sort paraneoplastic anti-n-methyl-d-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic t-cell-mediated pathology: case report
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440277/
https://www.ncbi.nlm.nih.gov/pubmed/36065447
http://dx.doi.org/10.3389/fimmu.2022.952868
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