DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates

Dumpy-30 (DPY30) is a conserved component of the mixed lineage leukemia (MLL) family complex and is essential for robust methyltransferase activity of MLL complexes. However, the biochemical role of DPY30 in stimulating methyltransferase activity of MLL complexes remains elusive. Here, we demonstrat...

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Detalles Bibliográficos
Autores principales: Zhao, Lijie, Huang, Naizhe, Mencius, Jun, Li, Yanjing, Xu, Ying, Zheng, Yongxin, He, Wei, Li, Na, Zheng, Jun, Zhuang, Min, Quan, Shu, Chen, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440282/
https://www.ncbi.nlm.nih.gov/pubmed/36065180
http://dx.doi.org/10.1016/j.isci.2022.104948

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