Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson diseases. Building on our previous studies of the neurodegenerative lysosomal lipidosis Niemann–Pick C1 (NPC1), we have un...

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Detalles Bibliográficos
Autores principales: Chen, Fannie W., Davies, Joanna P., Calvo, Raul, Chaudhari, Jagruti, Dolios, Georgia, Taylor, Mercedes K., Patnaik, Samarjit, Dehdashti, Jean, Mull, Rebecca, Dranchack, Patricia, Wang, Amy, Xu, Xin, Hughes, Emma, Southall, Noel, Ferrer, Marc, Wang, Rong, Marugan, Juan J., Ioannou, Yiannis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440283/
https://www.ncbi.nlm.nih.gov/pubmed/36065186
http://dx.doi.org/10.1016/j.isci.2022.104941

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