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Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma

Thyroid cancer is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) accounting for the majority of these cases. Cerebellar metastasis is rarely the presenting feature and confers poor prognosis. Genetic mutations in this setting are most commonly TERTp, in contrast to BRAF ( V...

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Autores principales: Wang, Mawson, Samra, Spinder, Chou, Shaun, Howle, Julie, Gild, Matti L., Girgis, Christian Meena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440345/
https://www.ncbi.nlm.nih.gov/pubmed/36093445
http://dx.doi.org/10.1002/ccr3.6207
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author Wang, Mawson
Samra, Spinder
Chou, Shaun
Howle, Julie
Gild, Matti L.
Girgis, Christian Meena
author_facet Wang, Mawson
Samra, Spinder
Chou, Shaun
Howle, Julie
Gild, Matti L.
Girgis, Christian Meena
author_sort Wang, Mawson
collection PubMed
description Thyroid cancer is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) accounting for the majority of these cases. Cerebellar metastasis is rarely the presenting feature and confers poor prognosis. Genetic mutations in this setting are most commonly TERTp, in contrast to BRAF ( V600E ) in the majority of PTC. We report the case of an 82 year‐old male who presented with a symptomatic right cerebellar lesion and underwent surgical resection to demonstrate metastatic PTC. Extensive workup with computed tomography, neck ultrasound and FDG‐PET was suggestive of a left thyroid primary lesion, with FNA confirming PTC. However, total thyroidectomy demonstrated incidental microMTC (medullary thyroid microcarcinoma, defined as tumour <10mm) without any evidence of PTC, whereas the left level VI neck dissection demonstrated a 30mm nodule of PTC without identifiable normal thyroid or lymph node tissue.
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spelling pubmed-94403452022-09-09 Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma Wang, Mawson Samra, Spinder Chou, Shaun Howle, Julie Gild, Matti L. Girgis, Christian Meena Clin Case Rep Case Report Thyroid cancer is the most common endocrine cancer, with papillary thyroid carcinoma (PTC) accounting for the majority of these cases. Cerebellar metastasis is rarely the presenting feature and confers poor prognosis. Genetic mutations in this setting are most commonly TERTp, in contrast to BRAF ( V600E ) in the majority of PTC. We report the case of an 82 year‐old male who presented with a symptomatic right cerebellar lesion and underwent surgical resection to demonstrate metastatic PTC. Extensive workup with computed tomography, neck ultrasound and FDG‐PET was suggestive of a left thyroid primary lesion, with FNA confirming PTC. However, total thyroidectomy demonstrated incidental microMTC (medullary thyroid microcarcinoma, defined as tumour <10mm) without any evidence of PTC, whereas the left level VI neck dissection demonstrated a 30mm nodule of PTC without identifiable normal thyroid or lymph node tissue. John Wiley and Sons Inc. 2022-09-02 /pmc/articles/PMC9440345/ /pubmed/36093445 http://dx.doi.org/10.1002/ccr3.6207 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Wang, Mawson
Samra, Spinder
Chou, Shaun
Howle, Julie
Gild, Matti L.
Girgis, Christian Meena
Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
title Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
title_full Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
title_fullStr Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
title_full_unstemmed Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
title_short Metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
title_sort metastatic papillary thyroid cancer to cerebellum with incidental medullary microcarcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440345/
https://www.ncbi.nlm.nih.gov/pubmed/36093445
http://dx.doi.org/10.1002/ccr3.6207
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