Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice

During obesity, tissue macrophages increase in number and become proinflammatory, thereby contributing to metabolic dysfunction. Lipoprotein lipase (LPL), which hydrolyzes triglyceride in lipoproteins, is secreted by macrophages. However, the role of macrophage-derived LPL in adipose tissue remodeli...

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Detalles Bibliográficos
Autores principales: Takahashi, Manabu, Yamamuro, Daisuke, Wakabayashi, Tetsuji, Takei, Akihito, Takei, Shoko, Nagashima, Shuichi, Okazaki, Hiroaki, Ebihara, Ken, Yagyu, Hiroaki, Takayanagi, Yuki, Onaka, Tatsushi, Goldberg, Ira J., Ishibashi, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440390/
https://www.ncbi.nlm.nih.gov/pubmed/35926714
http://dx.doi.org/10.1016/j.jbc.2022.102322

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