An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA

Many transcription factors contain intrinsically disordered transcription activation domains (TADs), which mediate interactions with coactivators to activate transcription. Historically, DNA-binding domains and TADs have been considered as modular units, but recent studies have shown that TADs can i...

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Detalles Bibliográficos
Autores principales: Baughman, Hannah E.R., Narang, Dominic, Chen, Wei, Villagrán Suárez, Amalia C., Lee, Joan, Bachochin, Maxwell J., Gunther, Tristan R., Wolynes, Peter G., Komives, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440430/
https://www.ncbi.nlm.nih.gov/pubmed/35934050
http://dx.doi.org/10.1016/j.jbc.2022.102349

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