Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt

Mechanistic target of rapamycin complex 2 (mTORC2) is a multi-subunit kinase complex, central to multiple essential signaling pathways. Two core subunits, Rictor and mSin1, distinguish it from the related mTORC1 and support context-dependent phosphorylation of its substrates. mTORC2 structures have...

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Detalles Bibliográficos
Autores principales: Yu, Zanlin, Chen, Junliang, Takagi, Enzo, Wang, Feng, Saha, Bidisha, Liu, Xi, Joubert, Lydia-Marie, Gleason, Catherine E., Jin, Mingliang, Li, Chengmin, Nowotny, Carlos, Agard, David, Cheng, Yifan, Pearce, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440446/
https://www.ncbi.nlm.nih.gov/pubmed/35926713
http://dx.doi.org/10.1016/j.jbc.2022.102288

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