Thymic self-antigen expression for immune tolerance and surveillance

T cells are a group of lymphocytes that play a central role in the immune system, notably, eliminating pathogens and attacking cancer while being tolerant of the self. Elucidating how immune tolerance is ensured has become a significant research issue for understanding the pathogenesis of autoimmune...

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Autores principales: Benlaribi, Rayene, Gou, Qiao, Takaba, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440513/
https://www.ncbi.nlm.nih.gov/pubmed/36056452
http://dx.doi.org/10.1186/s41232-022-00211-z
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author Benlaribi, Rayene
Gou, Qiao
Takaba, Hiroyuki
author_facet Benlaribi, Rayene
Gou, Qiao
Takaba, Hiroyuki
author_sort Benlaribi, Rayene
collection PubMed
description T cells are a group of lymphocytes that play a central role in the immune system, notably, eliminating pathogens and attacking cancer while being tolerant of the self. Elucidating how immune tolerance is ensured has become a significant research issue for understanding the pathogenesis of autoimmune diseases as well as cancer immunity. T cell immune tolerance is established mainly in the thymic medulla by the removal of self-responsive T cells and the generation of regulatory T cells, this process depends mainly on the expression of a variety of tissue restricted antigens (TRAs) by medullary thymic epithelial cells (mTECs). The expression of TRAs is known to be regulated by at least two independent factors, Fezf2 and Aire, which play non-redundant and complementary roles by different mechanisms. In this review, we introduce the molecular logic of thymic self-antigen expression that underlies T cell selection for the prevention of autoimmunity and the establishment of immune surveillance.
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spelling pubmed-94405132022-09-04 Thymic self-antigen expression for immune tolerance and surveillance Benlaribi, Rayene Gou, Qiao Takaba, Hiroyuki Inflamm Regen Review T cells are a group of lymphocytes that play a central role in the immune system, notably, eliminating pathogens and attacking cancer while being tolerant of the self. Elucidating how immune tolerance is ensured has become a significant research issue for understanding the pathogenesis of autoimmune diseases as well as cancer immunity. T cell immune tolerance is established mainly in the thymic medulla by the removal of self-responsive T cells and the generation of regulatory T cells, this process depends mainly on the expression of a variety of tissue restricted antigens (TRAs) by medullary thymic epithelial cells (mTECs). The expression of TRAs is known to be regulated by at least two independent factors, Fezf2 and Aire, which play non-redundant and complementary roles by different mechanisms. In this review, we introduce the molecular logic of thymic self-antigen expression that underlies T cell selection for the prevention of autoimmunity and the establishment of immune surveillance. BioMed Central 2022-09-03 /pmc/articles/PMC9440513/ /pubmed/36056452 http://dx.doi.org/10.1186/s41232-022-00211-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Benlaribi, Rayene
Gou, Qiao
Takaba, Hiroyuki
Thymic self-antigen expression for immune tolerance and surveillance
title Thymic self-antigen expression for immune tolerance and surveillance
title_full Thymic self-antigen expression for immune tolerance and surveillance
title_fullStr Thymic self-antigen expression for immune tolerance and surveillance
title_full_unstemmed Thymic self-antigen expression for immune tolerance and surveillance
title_short Thymic self-antigen expression for immune tolerance and surveillance
title_sort thymic self-antigen expression for immune tolerance and surveillance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440513/
https://www.ncbi.nlm.nih.gov/pubmed/36056452
http://dx.doi.org/10.1186/s41232-022-00211-z
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AT takabahiroyuki thymicselfantigenexpressionforimmunetoleranceandsurveillance

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