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Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline
BACKGROUND: Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in cognitive function and emotional responses and is generally aberrant in SCD. However, previous studies have mainly...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440588/ https://www.ncbi.nlm.nih.gov/pubmed/36057586 http://dx.doi.org/10.1186/s13195-022-01066-9 |
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author | Wang, Qiang Chen, Ben Zhong, Xiaomei Hou, Le Zhang, Min Yang, Mingfeng Wu, Zhangying Chen, Xinru Mai, Naikeng Zhou, Huarong Lin, Gaohong Zhang, Si Ning, Yuping |
author_facet | Wang, Qiang Chen, Ben Zhong, Xiaomei Hou, Le Zhang, Min Yang, Mingfeng Wu, Zhangying Chen, Xinru Mai, Naikeng Zhou, Huarong Lin, Gaohong Zhang, Si Ning, Yuping |
author_sort | Wang, Qiang |
collection | PubMed |
description | BACKGROUND: Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in cognitive function and emotional responses and is generally aberrant in SCD. However, previous studies have mainly focused on static functional connectivity (sFC) by resting-state functional magnetic resonance imaging (fMRI) in SCD individuals, and it remains unclear whether hippocampal dynamic functional connectivity (dFC) changes exist in SCD and whether those changes are associated with subtle changes in cognitive function or affect. METHODS: Seventy SCD patients and 65 healthy controls were recruited. Demographic data, comprehensive neuropsychology assessments, and resting-state fMRI data were collected. The bilateral anterior and posterior hippocampi were selected as seeds to investigate the static and dynamic functional connectivity alterations in SCD. RESULTS: Compared to healthy controls, subjects with SCD exhibited: (1) decreased sFC between the left caudal hippocampus and left precuneus; (2) decreased dFC variability between the bilateral caudal hippocampus and precuneus; (3) increased dFC variability between the bilateral rostral hippocampus and caudate nucleus; and (4) increased dFC variability between the left rostral hippocampus and left olfactory cortex. Additionally, the attention scores were positively correlated with dFC variability between the left posterior hippocampus and left precuneus, and the dFC variability between the bilateral anterior hippocampus and caudate nucleus was positively correlated with depression scores and negatively correlated with global cognition scores. CONCLUSION: SCD individuals exhibited abnormal sFC and dFC in the anterior-posterior hippocampus, and abnormal dFC was more widespread than abnormal sFC. A combination of sFC and dFC provides a new perspective for exploring the brain pathophysiological mechanisms in SCD and offers potential neuroimaging biomarkers for the early diagnosis and intervention of AD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-022-01066-9. |
format | Online Article Text |
id | pubmed-9440588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94405882022-09-04 Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline Wang, Qiang Chen, Ben Zhong, Xiaomei Hou, Le Zhang, Min Yang, Mingfeng Wu, Zhangying Chen, Xinru Mai, Naikeng Zhou, Huarong Lin, Gaohong Zhang, Si Ning, Yuping Alzheimers Res Ther Research BACKGROUND: Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in cognitive function and emotional responses and is generally aberrant in SCD. However, previous studies have mainly focused on static functional connectivity (sFC) by resting-state functional magnetic resonance imaging (fMRI) in SCD individuals, and it remains unclear whether hippocampal dynamic functional connectivity (dFC) changes exist in SCD and whether those changes are associated with subtle changes in cognitive function or affect. METHODS: Seventy SCD patients and 65 healthy controls were recruited. Demographic data, comprehensive neuropsychology assessments, and resting-state fMRI data were collected. The bilateral anterior and posterior hippocampi were selected as seeds to investigate the static and dynamic functional connectivity alterations in SCD. RESULTS: Compared to healthy controls, subjects with SCD exhibited: (1) decreased sFC between the left caudal hippocampus and left precuneus; (2) decreased dFC variability between the bilateral caudal hippocampus and precuneus; (3) increased dFC variability between the bilateral rostral hippocampus and caudate nucleus; and (4) increased dFC variability between the left rostral hippocampus and left olfactory cortex. Additionally, the attention scores were positively correlated with dFC variability between the left posterior hippocampus and left precuneus, and the dFC variability between the bilateral anterior hippocampus and caudate nucleus was positively correlated with depression scores and negatively correlated with global cognition scores. CONCLUSION: SCD individuals exhibited abnormal sFC and dFC in the anterior-posterior hippocampus, and abnormal dFC was more widespread than abnormal sFC. A combination of sFC and dFC provides a new perspective for exploring the brain pathophysiological mechanisms in SCD and offers potential neuroimaging biomarkers for the early diagnosis and intervention of AD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-022-01066-9. BioMed Central 2022-09-03 /pmc/articles/PMC9440588/ /pubmed/36057586 http://dx.doi.org/10.1186/s13195-022-01066-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wang, Qiang Chen, Ben Zhong, Xiaomei Hou, Le Zhang, Min Yang, Mingfeng Wu, Zhangying Chen, Xinru Mai, Naikeng Zhou, Huarong Lin, Gaohong Zhang, Si Ning, Yuping Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
title | Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
title_full | Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
title_fullStr | Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
title_full_unstemmed | Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
title_short | Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
title_sort | static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440588/ https://www.ncbi.nlm.nih.gov/pubmed/36057586 http://dx.doi.org/10.1186/s13195-022-01066-9 |
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