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Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation

BACKGROUND: Adequate donor and recipient matching in liver transplantation is crucial to improve patient survival. Our objective was to propose and validate a new model for predicting outcomes using donor and recipient scoring criteria. MATERIAL/METHODS: We retrospectively analyzed data of all patie...

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Autores principales: Nacif, Lucas Souto, Waisberg, Daniel Reis, Zanini, Leonardo Yuri, Pinheiro, Rafael Soares, Rocha-Santos, Vinicius, Macedo, Rubens Arantes, Ducatti, Liliana, Haddad, Luciana, de Martino, Rodrigo Bronze, Galvão, Flávio, Andraus, Wellington, Carneiro-D’Albuquerque, Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440620/
https://www.ncbi.nlm.nih.gov/pubmed/36039026
http://dx.doi.org/10.12659/AOT.936271
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author Nacif, Lucas Souto
Waisberg, Daniel Reis
Zanini, Leonardo Yuri
Pinheiro, Rafael Soares
Rocha-Santos, Vinicius
Macedo, Rubens Arantes
Ducatti, Liliana
Haddad, Luciana
de Martino, Rodrigo Bronze
Galvão, Flávio
Andraus, Wellington
Carneiro-D’Albuquerque, Luiz
author_facet Nacif, Lucas Souto
Waisberg, Daniel Reis
Zanini, Leonardo Yuri
Pinheiro, Rafael Soares
Rocha-Santos, Vinicius
Macedo, Rubens Arantes
Ducatti, Liliana
Haddad, Luciana
de Martino, Rodrigo Bronze
Galvão, Flávio
Andraus, Wellington
Carneiro-D’Albuquerque, Luiz
author_sort Nacif, Lucas Souto
collection PubMed
description BACKGROUND: Adequate donor and recipient matching in liver transplantation is crucial to improve patient survival. Our objective was to propose and validate a new model for predicting outcomes using donor and recipient scoring criteria. MATERIAL/METHODS: We retrospectively analyzed data of all patients (n=932) who underwent liver transplantation (n=1106) from January 2006 to December 2018. For score standardization, 30% (n=280) of patients were randomly selected for analysis and divided into 3 categories: ≤4 points, 5 to 8 points, and >8 points. Scoring system validation was performed on a dataset with 70% (n=652) of the patients. RESULTS: Survival of the stratified group (30%) was significant (P<0.001). Scores of 4 to 8 points presented lower risk of death (1.74 [CI 0.97–3.13; P=0.062]), while >8 points presented higher risk (2.74 [CI 1.36–5.57; P=0.005]). In the validation score (70%), global survival was significant (P<0.0016); patients with scores of 4 to 8 points had lower risk of death (1.16 [CI 1.16–2.38; P=0.005]); and scores >8 points (2.22 [CI 1.40–3.50; P<0.001]), retransplant, fulminant hepatitis, previous large abdominal/biliary tree surgery, MELD score, and serum creatinine before liver transplantation >1.5 mg/dL (P<0.05) presented higher risk. Individual recipient factors with 4 to 8 points had a lower risk of death (2.29 [CI 1.82–2.87; P<0.0001]) than those with scores >8 points (4.02 [CI 2.22–7.26; P<0.0001]). CONCLUSIONS: A novel prognostic-based scoring system using donor and recipient characteristics was proposed and clinically validated. Two-factor scoring indicated the superiority of the predictability outcome and improved prediction of higher mortality.
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spelling pubmed-94406202022-09-19 Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation Nacif, Lucas Souto Waisberg, Daniel Reis Zanini, Leonardo Yuri Pinheiro, Rafael Soares Rocha-Santos, Vinicius Macedo, Rubens Arantes Ducatti, Liliana Haddad, Luciana de Martino, Rodrigo Bronze Galvão, Flávio Andraus, Wellington Carneiro-D’Albuquerque, Luiz Ann Transplant Original Paper BACKGROUND: Adequate donor and recipient matching in liver transplantation is crucial to improve patient survival. Our objective was to propose and validate a new model for predicting outcomes using donor and recipient scoring criteria. MATERIAL/METHODS: We retrospectively analyzed data of all patients (n=932) who underwent liver transplantation (n=1106) from January 2006 to December 2018. For score standardization, 30% (n=280) of patients were randomly selected for analysis and divided into 3 categories: ≤4 points, 5 to 8 points, and >8 points. Scoring system validation was performed on a dataset with 70% (n=652) of the patients. RESULTS: Survival of the stratified group (30%) was significant (P<0.001). Scores of 4 to 8 points presented lower risk of death (1.74 [CI 0.97–3.13; P=0.062]), while >8 points presented higher risk (2.74 [CI 1.36–5.57; P=0.005]). In the validation score (70%), global survival was significant (P<0.0016); patients with scores of 4 to 8 points had lower risk of death (1.16 [CI 1.16–2.38; P=0.005]); and scores >8 points (2.22 [CI 1.40–3.50; P<0.001]), retransplant, fulminant hepatitis, previous large abdominal/biliary tree surgery, MELD score, and serum creatinine before liver transplantation >1.5 mg/dL (P<0.05) presented higher risk. Individual recipient factors with 4 to 8 points had a lower risk of death (2.29 [CI 1.82–2.87; P<0.0001]) than those with scores >8 points (4.02 [CI 2.22–7.26; P<0.0001]). CONCLUSIONS: A novel prognostic-based scoring system using donor and recipient characteristics was proposed and clinically validated. Two-factor scoring indicated the superiority of the predictability outcome and improved prediction of higher mortality. International Scientific Literature, Inc. 2022-08-30 /pmc/articles/PMC9440620/ /pubmed/36039026 http://dx.doi.org/10.12659/AOT.936271 Text en © Ann Transplant, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Original Paper
Nacif, Lucas Souto
Waisberg, Daniel Reis
Zanini, Leonardo Yuri
Pinheiro, Rafael Soares
Rocha-Santos, Vinicius
Macedo, Rubens Arantes
Ducatti, Liliana
Haddad, Luciana
de Martino, Rodrigo Bronze
Galvão, Flávio
Andraus, Wellington
Carneiro-D’Albuquerque, Luiz
Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation
title Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation
title_full Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation
title_fullStr Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation
title_full_unstemmed Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation
title_short Clinical Validation of a Novel Scoring System Based on Donor and Recipient Risk Factors for Predicting Outcomes in Liver Transplantation
title_sort clinical validation of a novel scoring system based on donor and recipient risk factors for predicting outcomes in liver transplantation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440620/
https://www.ncbi.nlm.nih.gov/pubmed/36039026
http://dx.doi.org/10.12659/AOT.936271
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