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Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study

PURPOSE: Cancer is one of the leading causes of mortality and morbidity, and therefore, tremendous research work is continuously being done around the world with consideration of etiopathogenesis as well as identification of therapeutic targets. Decades of continuous war in Afghanistan has left the...

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Autores principales: Malakzai, Haider Ali, Haidary, Ahmed Maseh, Gulzar, Saleema, Haidari, Mujtaba, Ibrahimkhil, Abdul Sami, Saadaat, Ramin, Hakimi, Ahmadullah, Sadat Hofiani, Sayed Murtaza, Rahmani, Soma, Abdul-Ghafar, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440704/
https://www.ncbi.nlm.nih.gov/pubmed/36065259
http://dx.doi.org/10.2147/CMAR.S377710
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author Malakzai, Haider Ali
Haidary, Ahmed Maseh
Gulzar, Saleema
Haidari, Mujtaba
Ibrahimkhil, Abdul Sami
Saadaat, Ramin
Hakimi, Ahmadullah
Sadat Hofiani, Sayed Murtaza
Rahmani, Soma
Abdul-Ghafar, Jamshid
author_facet Malakzai, Haider Ali
Haidary, Ahmed Maseh
Gulzar, Saleema
Haidari, Mujtaba
Ibrahimkhil, Abdul Sami
Saadaat, Ramin
Hakimi, Ahmadullah
Sadat Hofiani, Sayed Murtaza
Rahmani, Soma
Abdul-Ghafar, Jamshid
author_sort Malakzai, Haider Ali
collection PubMed
description PURPOSE: Cancer is one of the leading causes of mortality and morbidity, and therefore, tremendous research work is continuously being done around the world with consideration of etiopathogenesis as well as identification of therapeutic targets. Decades of continuous war in Afghanistan has left the medical infrastructure of the country in a miserable situation. There is a serious deficiency in research work in the fields of pathology and oncology at the moment with minimal data available to elaborate about the demographic characteristics of various malignant disorders in the country, which would be indispensable to pave the way for further research and development. PATIENTS AND METHODS: A descriptive cross-sectional study was conducted to describe the prevalence, distribution, and important histopathological features of malignant tumors reported at tertiary level in Afghanistan. RESULTS: Out of 2328 consecutive cases of solid malignant tumors included in our study, 93.8% were primary and 6.2% were metastatic. Breast was the most common site of origin for primary malignancy (29.5%) in females; however, in males, esophagus was the leading site for primary malignant tumors (16.3%). Invasive ductal carcinoma was the most common histologic type of malignancy in females (87.9%). However, in both genders, squamous cell carcinoma of esophagus and skin, osteosarcoma of bone and soft tissue, and glioblastoma of central nervous system were the most common histologic types of malignancies diagnosed. Small intestine was a frequently involved site affected by extranodal non-Hodgkin lymphomas. Overall, the majority of the cancers were diagnosed in stage-II. CONCLUSION: Findings in our study were somewhat similar to data presented elsewhere in the world, with some significant differences that could be related to the local factors. Our study revealed that most of the malignant tumors were diagnosed in later stages of the disease, attributable to scarcity of specialized oncology institutions and public awareness.
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spelling pubmed-94407042022-09-04 Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study Malakzai, Haider Ali Haidary, Ahmed Maseh Gulzar, Saleema Haidari, Mujtaba Ibrahimkhil, Abdul Sami Saadaat, Ramin Hakimi, Ahmadullah Sadat Hofiani, Sayed Murtaza Rahmani, Soma Abdul-Ghafar, Jamshid Cancer Manag Res Original Research PURPOSE: Cancer is one of the leading causes of mortality and morbidity, and therefore, tremendous research work is continuously being done around the world with consideration of etiopathogenesis as well as identification of therapeutic targets. Decades of continuous war in Afghanistan has left the medical infrastructure of the country in a miserable situation. There is a serious deficiency in research work in the fields of pathology and oncology at the moment with minimal data available to elaborate about the demographic characteristics of various malignant disorders in the country, which would be indispensable to pave the way for further research and development. PATIENTS AND METHODS: A descriptive cross-sectional study was conducted to describe the prevalence, distribution, and important histopathological features of malignant tumors reported at tertiary level in Afghanistan. RESULTS: Out of 2328 consecutive cases of solid malignant tumors included in our study, 93.8% were primary and 6.2% were metastatic. Breast was the most common site of origin for primary malignancy (29.5%) in females; however, in males, esophagus was the leading site for primary malignant tumors (16.3%). Invasive ductal carcinoma was the most common histologic type of malignancy in females (87.9%). However, in both genders, squamous cell carcinoma of esophagus and skin, osteosarcoma of bone and soft tissue, and glioblastoma of central nervous system were the most common histologic types of malignancies diagnosed. Small intestine was a frequently involved site affected by extranodal non-Hodgkin lymphomas. Overall, the majority of the cancers were diagnosed in stage-II. CONCLUSION: Findings in our study were somewhat similar to data presented elsewhere in the world, with some significant differences that could be related to the local factors. Our study revealed that most of the malignant tumors were diagnosed in later stages of the disease, attributable to scarcity of specialized oncology institutions and public awareness. Dove 2022-08-30 /pmc/articles/PMC9440704/ /pubmed/36065259 http://dx.doi.org/10.2147/CMAR.S377710 Text en © 2022 Malakzai et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Malakzai, Haider Ali
Haidary, Ahmed Maseh
Gulzar, Saleema
Haidari, Mujtaba
Ibrahimkhil, Abdul Sami
Saadaat, Ramin
Hakimi, Ahmadullah
Sadat Hofiani, Sayed Murtaza
Rahmani, Soma
Abdul-Ghafar, Jamshid
Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study
title Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study
title_full Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study
title_fullStr Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study
title_full_unstemmed Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study
title_short Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study
title_sort prevalence, distribution, and histopathological features of malignant tumors reported at tertiary level in afghanistan: a 3-year study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440704/
https://www.ncbi.nlm.nih.gov/pubmed/36065259
http://dx.doi.org/10.2147/CMAR.S377710
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