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Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia
BACKGROUND: To evaluate the neuroretina and retinal vasculature of fibromyalgia (FM) patients and calculate a linear discriminant function (LDF) to improve retinal parameters' contribution to FM diagnosis. METHODS: Fifty FM patients and 232 healthy controls underwent retinal evaluation using sw...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440831/ https://www.ncbi.nlm.nih.gov/pubmed/36065284 http://dx.doi.org/10.1155/2022/3946017 |
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author | Garcia-Martin, Elena Tello, Alvaro Vilades, Elisa Perez-Velilla, Javier Cordon, Beatriz Fernandez-Velasco, Diego Garcia-Campayo, Javier Puebla-Guedea, Marta Satue, Maria |
author_facet | Garcia-Martin, Elena Tello, Alvaro Vilades, Elisa Perez-Velilla, Javier Cordon, Beatriz Fernandez-Velasco, Diego Garcia-Campayo, Javier Puebla-Guedea, Marta Satue, Maria |
author_sort | Garcia-Martin, Elena |
collection | PubMed |
description | BACKGROUND: To evaluate the neuroretina and retinal vasculature of fibromyalgia (FM) patients and calculate a linear discriminant function (LDF) to improve retinal parameters' contribution to FM diagnosis. METHODS: Fifty FM patients and 232 healthy controls underwent retinal evaluation using swept-source optical coherence tomography (SS-OCT) angiography (Triton plus; Topcon) and spectral domain OCT (SD-OCT) (Spectralis; Heidelberg). The macular (m) and peripapillary (p) retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) were assessed, as was the macular vascular density. A logistic regression analysis was performed, and an LDF was calculated to evaluate OCT's contribution to FM diagnosis. RESULTS: With Triton OCT, the patients presented pRNFL thinning in the temporal sector (p=0.006). Spectralis OCT measurements showed decreased pRNFL in patients in the following sectors: superonasal, p=0.001; nasal, p=0.001; inferonasal, p=0.006; temporal, p=0.001; and inferotemporal, p=0.001. No significant differences were observed in the macular vascular plexus between patients and controls. However, vascular density in the superior sector showed a strong inverse correlation with disease duration (r = −0.978, p=0.022). The LDF calculated for Spectralis OCT yielded an area under the ROC curve of 0.968. CONCLUSIONS: FM patients present RNFL thinning observable using SS- and SD-OCT. However, these patients show similar vascular density in the macular area to healthy controls. The LDF that combines several RNFL parameters obtained using Spectralis OCT gives this device a powerful ability to differentiate between healthy individuals and individuals with FM. |
format | Online Article Text |
id | pubmed-9440831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94408312022-09-04 Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia Garcia-Martin, Elena Tello, Alvaro Vilades, Elisa Perez-Velilla, Javier Cordon, Beatriz Fernandez-Velasco, Diego Garcia-Campayo, Javier Puebla-Guedea, Marta Satue, Maria J Ophthalmol Research Article BACKGROUND: To evaluate the neuroretina and retinal vasculature of fibromyalgia (FM) patients and calculate a linear discriminant function (LDF) to improve retinal parameters' contribution to FM diagnosis. METHODS: Fifty FM patients and 232 healthy controls underwent retinal evaluation using swept-source optical coherence tomography (SS-OCT) angiography (Triton plus; Topcon) and spectral domain OCT (SD-OCT) (Spectralis; Heidelberg). The macular (m) and peripapillary (p) retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) were assessed, as was the macular vascular density. A logistic regression analysis was performed, and an LDF was calculated to evaluate OCT's contribution to FM diagnosis. RESULTS: With Triton OCT, the patients presented pRNFL thinning in the temporal sector (p=0.006). Spectralis OCT measurements showed decreased pRNFL in patients in the following sectors: superonasal, p=0.001; nasal, p=0.001; inferonasal, p=0.006; temporal, p=0.001; and inferotemporal, p=0.001. No significant differences were observed in the macular vascular plexus between patients and controls. However, vascular density in the superior sector showed a strong inverse correlation with disease duration (r = −0.978, p=0.022). The LDF calculated for Spectralis OCT yielded an area under the ROC curve of 0.968. CONCLUSIONS: FM patients present RNFL thinning observable using SS- and SD-OCT. However, these patients show similar vascular density in the macular area to healthy controls. The LDF that combines several RNFL parameters obtained using Spectralis OCT gives this device a powerful ability to differentiate between healthy individuals and individuals with FM. Hindawi 2022-08-27 /pmc/articles/PMC9440831/ /pubmed/36065284 http://dx.doi.org/10.1155/2022/3946017 Text en Copyright © 2022 Elena Garcia-Martin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Garcia-Martin, Elena Tello, Alvaro Vilades, Elisa Perez-Velilla, Javier Cordon, Beatriz Fernandez-Velasco, Diego Garcia-Campayo, Javier Puebla-Guedea, Marta Satue, Maria Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia |
title | Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia |
title_full | Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia |
title_fullStr | Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia |
title_full_unstemmed | Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia |
title_short | Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia |
title_sort | diagnostic ability and capacity of optical coherence tomography-angiography to detect retinal and vascular changes in patients with fibromyalgia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440831/ https://www.ncbi.nlm.nih.gov/pubmed/36065284 http://dx.doi.org/10.1155/2022/3946017 |
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