circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation

BACKGROUND: The BCR-ABL fusion protein is the key factor that results in the occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR-ABL to achieve complete remission. However, remission failure occurs due to acquired resistance caused by secondary BCR-ABL mutation...

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Detalles Bibliográficos
Autores principales: Wang, Jianming, Liang, Yang, Qin, Yuefeng, Jiang, Guoyun, Peng, Yuhang, Feng, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440867/
https://www.ncbi.nlm.nih.gov/pubmed/36058922
http://dx.doi.org/10.1186/s12967-022-03586-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440867/
https://www.ncbi.nlm.nih.gov/pubmed/36058922
http://dx.doi.org/10.1186/s12967-022-03586-2

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