Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity

Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs to the NAD(+)-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Here, we report that IEC Sirt6 deletio...

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Detalles Bibliográficos
Autores principales: Xiong, Xiwen, Yang, Chenyan, He, Wei-Qi, Yu, Jiahui, Xin, Yue, Zhang, Xinge, Huang, Rong, Ma, Honghui, Xu, Shaofang, Li, Zun, Ma, Jie, Xu, Lin, Wang, Qunyi, Ren, Kaiqun, Wu, Xiaoli S., Vakoc, Christopher R., Zhong, Jiateng, Zhong, Genshen, Zhu, Xiaofei, Song, Yu, Ruan, Hai-Bin, Wang, Qingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440928/
https://www.ncbi.nlm.nih.gov/pubmed/36057627
http://dx.doi.org/10.1038/s41467-022-32846-4

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