Cargando…

Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota

Edible mushrooms have now been suggested as promising sources of biological functional ingredients and are the subject of the most recent nutrition research and novel functional foods. Polysaccharides from mushrooms exhibit impressive biological effects, notably against obesity. Obesity is a chronic...

Descripción completa

Detalles Bibliográficos
Autores principales: Rehman, Ata Ur, Khan, Asif Iqbal, Xin, Yi, Liang, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440975/
https://www.ncbi.nlm.nih.gov/pubmed/36056976
http://dx.doi.org/10.1186/s13568-022-01451-5
_version_ 1784782475127422976
author Rehman, Ata Ur
Khan, Asif Iqbal
Xin, Yi
Liang, Wang
author_facet Rehman, Ata Ur
Khan, Asif Iqbal
Xin, Yi
Liang, Wang
author_sort Rehman, Ata Ur
collection PubMed
description Edible mushrooms have now been suggested as promising sources of biological functional ingredients and are the subject of the most recent nutrition research and novel functional foods. Polysaccharides from mushrooms exhibit impressive biological effects, notably against obesity. Obesity is a chronic metabolic disorder characterized by chronic inflammation, gut dysbiosis, and hyperpermeability of the colon. Here, we prove that mushrooms Morchella esculenta polysaccharide (MEP) effects on HFD-induced obesity, colonic inflammation, and gut microbiota dysbiosis. Our findings demonstrate MEP supplementation attenuates obesity parameters and reduces inflammation in the colon via regulation of Toll-like receptor 4 (TLR4), nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inactivation of nuclear factor kappa B (NF-κB). Furthermore, MEP administration restores gut microbiota dysregulation by ameliorating Firmicutes to Bacteroidetes proportion as well as enhancing beneficial bacteria, like Lactobacillus, and inhibiting pathogenic bacteria like Enterococcus. MEP improves gut integrity by increasing tight junction proteins (TJs) and reducing endotoxin levels by controlling Lipopolysaccharide (LPS) in HFD-induced obese mice. These results demonstrated the therapeutic efficacy of MEP in attenuating HFD-induced obesity via regulating inflammatory cascades, ameliorating the gut microbiome, and modulating gut integrity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13568-022-01451-5.
format Online
Article
Text
id pubmed-9440975
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-94409752022-09-05 Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota Rehman, Ata Ur Khan, Asif Iqbal Xin, Yi Liang, Wang AMB Express Original Article Edible mushrooms have now been suggested as promising sources of biological functional ingredients and are the subject of the most recent nutrition research and novel functional foods. Polysaccharides from mushrooms exhibit impressive biological effects, notably against obesity. Obesity is a chronic metabolic disorder characterized by chronic inflammation, gut dysbiosis, and hyperpermeability of the colon. Here, we prove that mushrooms Morchella esculenta polysaccharide (MEP) effects on HFD-induced obesity, colonic inflammation, and gut microbiota dysbiosis. Our findings demonstrate MEP supplementation attenuates obesity parameters and reduces inflammation in the colon via regulation of Toll-like receptor 4 (TLR4), nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inactivation of nuclear factor kappa B (NF-κB). Furthermore, MEP administration restores gut microbiota dysregulation by ameliorating Firmicutes to Bacteroidetes proportion as well as enhancing beneficial bacteria, like Lactobacillus, and inhibiting pathogenic bacteria like Enterococcus. MEP improves gut integrity by increasing tight junction proteins (TJs) and reducing endotoxin levels by controlling Lipopolysaccharide (LPS) in HFD-induced obese mice. These results demonstrated the therapeutic efficacy of MEP in attenuating HFD-induced obesity via regulating inflammatory cascades, ameliorating the gut microbiome, and modulating gut integrity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13568-022-01451-5. Springer Berlin Heidelberg 2022-09-03 /pmc/articles/PMC9440975/ /pubmed/36056976 http://dx.doi.org/10.1186/s13568-022-01451-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Rehman, Ata Ur
Khan, Asif Iqbal
Xin, Yi
Liang, Wang
Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
title Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
title_full Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
title_fullStr Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
title_full_unstemmed Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
title_short Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
title_sort morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440975/
https://www.ncbi.nlm.nih.gov/pubmed/36056976
http://dx.doi.org/10.1186/s13568-022-01451-5
work_keys_str_mv AT rehmanataur morchellaesculentapolysaccharideattenuateobesityinflammationandmodulategutmicrobiota
AT khanasifiqbal morchellaesculentapolysaccharideattenuateobesityinflammationandmodulategutmicrobiota
AT xinyi morchellaesculentapolysaccharideattenuateobesityinflammationandmodulategutmicrobiota
AT liangwang morchellaesculentapolysaccharideattenuateobesityinflammationandmodulategutmicrobiota