Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report

Proximal renal tubular acidosis (type 2 RTA) is a metabolic disorder characterized by an inability of the proximal renal tubules to reabsorb bicarbonate, resulting in excessive urinary loss of bicarbonate. In return, this causes a standard anion gap metabolic acidosis with aberrant renal acidificati...

Descripción completa

Detalles Bibliográficos
Autores principales: Chukwuedozie, Vivian C, Garg, Tulika, Chaudhry, Hassan A, Shawl, Saima H, Mishra, Priya, Adaralegbe, Ngozi J, Khan, Aadil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440985/
https://www.ncbi.nlm.nih.gov/pubmed/36081958
http://dx.doi.org/10.7759/cureus.27695
_version_ 1784782477322092544
author Chukwuedozie, Vivian C
Garg, Tulika
Chaudhry, Hassan A
Shawl, Saima H
Mishra, Priya
Adaralegbe, Ngozi J
Khan, Aadil
author_facet Chukwuedozie, Vivian C
Garg, Tulika
Chaudhry, Hassan A
Shawl, Saima H
Mishra, Priya
Adaralegbe, Ngozi J
Khan, Aadil
author_sort Chukwuedozie, Vivian C
collection PubMed
description Proximal renal tubular acidosis (type 2 RTA) is a metabolic disorder characterized by an inability of the proximal renal tubules to reabsorb bicarbonate, resulting in excessive urinary loss of bicarbonate. In return, this causes a standard anion gap metabolic acidosis with aberrant renal acidification, culminating in excessive urinary potassium loss and hyperchloremic metabolic acidosis. Several sources can induce potassium deficiency, ranging from slight abnormalities in potassium homeostasis to catastrophic and occasionally lethal circumstances. Hypokalemic periodic paralysis (HPP) manifests with broad muscle weakness and the absence of deep tendon reflexes, with the facial, bulbar, and respiratory muscles spared, and it subsequently requires the administration of intravenous potassium chloride to address the potassium imbalance. Some patients suffering from chronic potassium shortage may have periods of weakness. The clinical symptoms of distal RTA are identical to those of attacks induced by familial hypokalemic periodic paralysis (FPP). Muscle weakness may begin slowly and worsen over 24-48 hours to flaccid quadriplegia. RTA and FPP typically spare speech, swallowing, and ocular and respiratory muscles. As a result, families with RTA children must be aware of this risk. We present a case of HPP in a female caused by type 2 RTA.
format Online
Article
Text
id pubmed-9440985
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-94409852022-09-07 Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report Chukwuedozie, Vivian C Garg, Tulika Chaudhry, Hassan A Shawl, Saima H Mishra, Priya Adaralegbe, Ngozi J Khan, Aadil Cureus Internal Medicine Proximal renal tubular acidosis (type 2 RTA) is a metabolic disorder characterized by an inability of the proximal renal tubules to reabsorb bicarbonate, resulting in excessive urinary loss of bicarbonate. In return, this causes a standard anion gap metabolic acidosis with aberrant renal acidification, culminating in excessive urinary potassium loss and hyperchloremic metabolic acidosis. Several sources can induce potassium deficiency, ranging from slight abnormalities in potassium homeostasis to catastrophic and occasionally lethal circumstances. Hypokalemic periodic paralysis (HPP) manifests with broad muscle weakness and the absence of deep tendon reflexes, with the facial, bulbar, and respiratory muscles spared, and it subsequently requires the administration of intravenous potassium chloride to address the potassium imbalance. Some patients suffering from chronic potassium shortage may have periods of weakness. The clinical symptoms of distal RTA are identical to those of attacks induced by familial hypokalemic periodic paralysis (FPP). Muscle weakness may begin slowly and worsen over 24-48 hours to flaccid quadriplegia. RTA and FPP typically spare speech, swallowing, and ocular and respiratory muscles. As a result, families with RTA children must be aware of this risk. We present a case of HPP in a female caused by type 2 RTA. Cureus 2022-08-05 /pmc/articles/PMC9440985/ /pubmed/36081958 http://dx.doi.org/10.7759/cureus.27695 Text en Copyright © 2022, Chukwuedozie et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Chukwuedozie, Vivian C
Garg, Tulika
Chaudhry, Hassan A
Shawl, Saima H
Mishra, Priya
Adaralegbe, Ngozi J
Khan, Aadil
Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report
title Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report
title_full Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report
title_fullStr Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report
title_full_unstemmed Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report
title_short Late-Onset Hypokalemic Periodic Paralysis in an Adult Female With Type 2 Renal Tubular Acidosis: A Case Report
title_sort late-onset hypokalemic periodic paralysis in an adult female with type 2 renal tubular acidosis: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440985/
https://www.ncbi.nlm.nih.gov/pubmed/36081958
http://dx.doi.org/10.7759/cureus.27695
work_keys_str_mv AT chukwuedozievivianc lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport
AT gargtulika lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport
AT chaudhryhassana lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport
AT shawlsaimah lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport
AT mishrapriya lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport
AT adaralegbengozij lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport
AT khanaadil lateonsethypokalemicperiodicparalysisinanadultfemalewithtype2renaltubularacidosisacasereport