Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

PURPOSE: Janus kinase 1 (JAK1) is implicated in multiple inflammatory pathways that are critical for the pathogenesis of asthma, including the interleukin (IL)-4, IL-5, IL-13, and thymic stromal lymphopoietin cytokine signaling pathways, which have previously been targeted to treat allergic asthma....

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Detalles Bibliográficos
Autores principales: Nilsson, Magnus, Rhedin, Magdalena, Hendrickx, Ramon, Berglund, Susanne, Piras, Antonio, Blomgran, Parmis, Cavallin, Anders, Collins, Mia, Dahl, Göran, Dekkak, Bilel, Ericsson, Therese, Hagberg, Niklas, Holmberg, Ann Aurell, Leffler, Agnes, Lundqvist, Anders J, Markou, Thomais, Pinkerton, James, Rönnblom, Lars, Siu, Stacey, Taylor, Vanessa, Wennberg, Tiiu, Zervas, Dimitrios, Laurence, Arian D J, Mitra, Suman, Belvisi, Maria G, Birrell, Mark, Borde, Annika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441147/
https://www.ncbi.nlm.nih.gov/pubmed/36068788
http://dx.doi.org/10.2147/DDDT.S354291

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