Cargando…

Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment

The incidence of fungal infections is increasing at an alarming rate and has posed a great challenge for science in recent years. The rise in these infections has been related to the increase in immunocompromised patients and the resistance of different species to antifungal drugs. Infections caused...

Descripción completa

Detalles Bibliográficos
Autores principales: Mendoza-Reyes, Diana F, Gómez-Gaviria, Manuela, Mora-Montes, Héctor M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441179/
https://www.ncbi.nlm.nih.gov/pubmed/36068831
http://dx.doi.org/10.2147/IDR.S383785
_version_ 1784782519522033664
author Mendoza-Reyes, Diana F
Gómez-Gaviria, Manuela
Mora-Montes, Héctor M
author_facet Mendoza-Reyes, Diana F
Gómez-Gaviria, Manuela
Mora-Montes, Héctor M
author_sort Mendoza-Reyes, Diana F
collection PubMed
description The incidence of fungal infections is increasing at an alarming rate and has posed a great challenge for science in recent years. The rise in these infections has been related to the increase in immunocompromised patients and the resistance of different species to antifungal drugs. Infections caused by the different Candida species, especially Candida albicans, are one of the most common mycoses in humans, and the etiological agents are considered opportunistic pathogens associated with high mortality rates when disseminated infections occur. Candida lusitaniae is considered an emerging opportunistic pathogen that most frequently affects immunocompromised patients with some comorbidity. Although it is a low-frequency pathogen, and the mortality rate of C. lusitaniae-caused candidemia does not exceed 5%, some isolates are known to be resistant to antifungals such as amphotericin B, 5-fluorocytosine, and fluconazole. In this paper, a detailed review of the current literature on this organism and its different aspects, such as its biology, possible virulence factors, pathogen-host interaction, diagnosis, and treatment of infection, is provided. Of particular interest, through Blastp analysis we predicted possible virulence factors in this species.
format Online
Article
Text
id pubmed-9441179
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-94411792022-09-05 Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment Mendoza-Reyes, Diana F Gómez-Gaviria, Manuela Mora-Montes, Héctor M Infect Drug Resist Review The incidence of fungal infections is increasing at an alarming rate and has posed a great challenge for science in recent years. The rise in these infections has been related to the increase in immunocompromised patients and the resistance of different species to antifungal drugs. Infections caused by the different Candida species, especially Candida albicans, are one of the most common mycoses in humans, and the etiological agents are considered opportunistic pathogens associated with high mortality rates when disseminated infections occur. Candida lusitaniae is considered an emerging opportunistic pathogen that most frequently affects immunocompromised patients with some comorbidity. Although it is a low-frequency pathogen, and the mortality rate of C. lusitaniae-caused candidemia does not exceed 5%, some isolates are known to be resistant to antifungals such as amphotericin B, 5-fluorocytosine, and fluconazole. In this paper, a detailed review of the current literature on this organism and its different aspects, such as its biology, possible virulence factors, pathogen-host interaction, diagnosis, and treatment of infection, is provided. Of particular interest, through Blastp analysis we predicted possible virulence factors in this species. Dove 2022-08-31 /pmc/articles/PMC9441179/ /pubmed/36068831 http://dx.doi.org/10.2147/IDR.S383785 Text en © 2022 Mendoza-Reyes et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Mendoza-Reyes, Diana F
Gómez-Gaviria, Manuela
Mora-Montes, Héctor M
Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
title Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
title_full Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
title_fullStr Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
title_full_unstemmed Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
title_short Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
title_sort candida lusitaniae: biology, pathogenicity, virulence factors, diagnosis, and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441179/
https://www.ncbi.nlm.nih.gov/pubmed/36068831
http://dx.doi.org/10.2147/IDR.S383785
work_keys_str_mv AT mendozareyesdianaf candidalusitaniaebiologypathogenicityvirulencefactorsdiagnosisandtreatment
AT gomezgaviriamanuela candidalusitaniaebiologypathogenicityvirulencefactorsdiagnosisandtreatment
AT moramonteshectorm candidalusitaniaebiologypathogenicityvirulencefactorsdiagnosisandtreatment