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Secretome as neuropathology-targeted intervention of Parkinson’s disease

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ⍺-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promi...

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Autores principales: Ardianto, Christian, Shen, Robert, Barus, Jimmy F.A., Sasmita, Poppy Kristina, Turana, Yuda, Lilis, Lilis, Sidharta, Veronika Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441294/
https://www.ncbi.nlm.nih.gov/pubmed/36092507
http://dx.doi.org/10.1016/j.reth.2022.08.003
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author Ardianto, Christian
Shen, Robert
Barus, Jimmy F.A.
Sasmita, Poppy Kristina
Turana, Yuda
Lilis, Lilis
Sidharta, Veronika Maria
author_facet Ardianto, Christian
Shen, Robert
Barus, Jimmy F.A.
Sasmita, Poppy Kristina
Turana, Yuda
Lilis, Lilis
Sidharta, Veronika Maria
author_sort Ardianto, Christian
collection PubMed
description Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ⍺-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promising preventive approaches that target several mechanisms in the neuropathology of PD. Its components target the lack of neurotrophin factors, proteasome dysfunction, oxidative stress, mitochondrial dysfunction, and at last neuroinflammation via several pathways. The complex and obscure pathology of PD induce the difficulty of the search of potential preventive approach for this disease. We described the potential of secretome of MSC as the novel preventive approach for PD, especially by targeting the said major pathogenesis of PD.
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spelling pubmed-94412942022-09-09 Secretome as neuropathology-targeted intervention of Parkinson’s disease Ardianto, Christian Shen, Robert Barus, Jimmy F.A. Sasmita, Poppy Kristina Turana, Yuda Lilis, Lilis Sidharta, Veronika Maria Regen Ther Review Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ⍺-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promising preventive approaches that target several mechanisms in the neuropathology of PD. Its components target the lack of neurotrophin factors, proteasome dysfunction, oxidative stress, mitochondrial dysfunction, and at last neuroinflammation via several pathways. The complex and obscure pathology of PD induce the difficulty of the search of potential preventive approach for this disease. We described the potential of secretome of MSC as the novel preventive approach for PD, especially by targeting the said major pathogenesis of PD. Japanese Society for Regenerative Medicine 2022-08-28 /pmc/articles/PMC9441294/ /pubmed/36092507 http://dx.doi.org/10.1016/j.reth.2022.08.003 Text en © 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ardianto, Christian
Shen, Robert
Barus, Jimmy F.A.
Sasmita, Poppy Kristina
Turana, Yuda
Lilis, Lilis
Sidharta, Veronika Maria
Secretome as neuropathology-targeted intervention of Parkinson’s disease
title Secretome as neuropathology-targeted intervention of Parkinson’s disease
title_full Secretome as neuropathology-targeted intervention of Parkinson’s disease
title_fullStr Secretome as neuropathology-targeted intervention of Parkinson’s disease
title_full_unstemmed Secretome as neuropathology-targeted intervention of Parkinson’s disease
title_short Secretome as neuropathology-targeted intervention of Parkinson’s disease
title_sort secretome as neuropathology-targeted intervention of parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441294/
https://www.ncbi.nlm.nih.gov/pubmed/36092507
http://dx.doi.org/10.1016/j.reth.2022.08.003
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