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Secretome as neuropathology-targeted intervention of Parkinson’s disease
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ⍺-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society for Regenerative Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441294/ https://www.ncbi.nlm.nih.gov/pubmed/36092507 http://dx.doi.org/10.1016/j.reth.2022.08.003 |
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author | Ardianto, Christian Shen, Robert Barus, Jimmy F.A. Sasmita, Poppy Kristina Turana, Yuda Lilis, Lilis Sidharta, Veronika Maria |
author_facet | Ardianto, Christian Shen, Robert Barus, Jimmy F.A. Sasmita, Poppy Kristina Turana, Yuda Lilis, Lilis Sidharta, Veronika Maria |
author_sort | Ardianto, Christian |
collection | PubMed |
description | Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ⍺-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promising preventive approaches that target several mechanisms in the neuropathology of PD. Its components target the lack of neurotrophin factors, proteasome dysfunction, oxidative stress, mitochondrial dysfunction, and at last neuroinflammation via several pathways. The complex and obscure pathology of PD induce the difficulty of the search of potential preventive approach for this disease. We described the potential of secretome of MSC as the novel preventive approach for PD, especially by targeting the said major pathogenesis of PD. |
format | Online Article Text |
id | pubmed-9441294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japanese Society for Regenerative Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-94412942022-09-09 Secretome as neuropathology-targeted intervention of Parkinson’s disease Ardianto, Christian Shen, Robert Barus, Jimmy F.A. Sasmita, Poppy Kristina Turana, Yuda Lilis, Lilis Sidharta, Veronika Maria Regen Ther Review Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, characterized by apoptosis of dopaminergic neurons in substansia nigra pars compacta (SNpc) caused by ⍺-synuclein aggregation. The use of secretomes released by medicinal signaling cells (MSCs) is one the promising preventive approaches that target several mechanisms in the neuropathology of PD. Its components target the lack of neurotrophin factors, proteasome dysfunction, oxidative stress, mitochondrial dysfunction, and at last neuroinflammation via several pathways. The complex and obscure pathology of PD induce the difficulty of the search of potential preventive approach for this disease. We described the potential of secretome of MSC as the novel preventive approach for PD, especially by targeting the said major pathogenesis of PD. Japanese Society for Regenerative Medicine 2022-08-28 /pmc/articles/PMC9441294/ /pubmed/36092507 http://dx.doi.org/10.1016/j.reth.2022.08.003 Text en © 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ardianto, Christian Shen, Robert Barus, Jimmy F.A. Sasmita, Poppy Kristina Turana, Yuda Lilis, Lilis Sidharta, Veronika Maria Secretome as neuropathology-targeted intervention of Parkinson’s disease |
title | Secretome as neuropathology-targeted intervention of Parkinson’s disease |
title_full | Secretome as neuropathology-targeted intervention of Parkinson’s disease |
title_fullStr | Secretome as neuropathology-targeted intervention of Parkinson’s disease |
title_full_unstemmed | Secretome as neuropathology-targeted intervention of Parkinson’s disease |
title_short | Secretome as neuropathology-targeted intervention of Parkinson’s disease |
title_sort | secretome as neuropathology-targeted intervention of parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441294/ https://www.ncbi.nlm.nih.gov/pubmed/36092507 http://dx.doi.org/10.1016/j.reth.2022.08.003 |
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