Cargando…

Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in PC12 cells. Knocking down Runx1 in dorsal root ganglion (D...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Zhu-Lin, Liu, Xiao-Dan, Zhang, Zi-Xian, Li, Song, Tian, Yue, Xi, Ke, Cai, Jie, Yang, Xiao-Mei, Liu, Min, Xing, Guo-Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441333/ https://www.ncbi.nlm.nih.gov/pubmed/36072549 http://dx.doi.org/10.1016/j.isci.2022.104936

Ejemplares similares

Mechanism of methylation and acetylation of high GDNF transcription in glioma cells: A review
por: Zhang, Lin, et al.
Publicado: (2019)

Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats
por: Liu, Jiang-Ping, et al.
Publicado: (2021)

GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF-1/SREBP-1
por: Yu, Zhi-Yun, et al.
Publicado: (2022)

Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells
por: Zhang, Baole, et al.
Publicado: (2020)

RUNX1-mediated alphaherpesvirus-host trans-species chromatin interaction promotes viral transcription
por: Xiao, Ke, et al.
Publicado: (2021)

Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype
por: Rasouli, Javad, et al.
Publicado: (2022)

The GDNF Family: A Role in Cancer?
por: Fielder, Graeme C., et al.
Publicado: (2017)

The Future of GDNF in Parkinson's Disease
por: Manfredsson, Fredric P., et al.
Publicado: (2020)

Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice
por: García-Caballero, Cristina, et al.
Publicado: (2018)

Blunt dopamine transmission due to decreased GDNF in the PFC evokes cognitive impairment in Parkinson’s disease
por: Tang, Chuan-Xi, et al.
Publicado: (2022)

Combination therapy using GDNF and cell transplant in Parkinson’s disease
por: Xiao, Bin, et al.
Publicado: (2022)

Runx transcription factors in neuronal development
por: Inoue, Ken-ichi, et al.
Publicado: (2008)

Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes
por: Ogawa, Eisaku, et al.
Publicado: (2022)

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3(+) inducible regulatory T cells
por: Klunker, Sven, et al.
Publicado: (2009)

The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia
por: Qin, Ya-Zhen, et al.
Publicado: (2017)

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
por: d’Anglemont de Tassigny, Xavier, et al.
Publicado: (2015)

TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells
por: Yin, Jingwen, et al.
Publicado: (2020)

Effects of Pulsed Radiofrequency on Nerve Repair and Expressions of GFAP and GDNF in Rats with Neuropathic Pain
por: Zhu, Qing, et al.
Publicado: (2021)

Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II
por: Zhang, Bao-Le, et al.
Publicado: (2017)

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
por: Illendula, Anuradha, et al.
Publicado: (2016)

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
por: Grinev, Vasily V., et al.
Publicado: (2021)

Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain
por: Liu, Xiao-Dan, et al.
Publicado: (2014)

Transcriptional Regulation of RUNX1: An Informatics Analysis
por: Thomas, Amarni L., et al.
Publicado: (2021)

GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries
por: Cintrón-Colón, Alberto F., et al.
Publicado: (2021)

The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasion
por: Liu, Songsong, et al.
Publicado: (2020)

APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF
por: Choi, Yoo-Duk, et al.
Publicado: (2020)

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
por: Egawa, Takeshi, et al.
Publicado: (2008)

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
por: Egawa, Takeshi, et al.
Publicado: (2007)

AAV-Mediated Combination Gene Therapy for Neuropathic Pain: GAD65, GDNF, and IL-10
por: Kim, Daewook, et al.
Publicado: (2020)

Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain
por: Xu, Wei, et al.
Publicado: (2022)

Improving therapeutic potential of GDNF family ligands
por: Runeberg-Roos, Pia, et al.
Publicado: (2020)

Cellular Localization of gdnf in Adult Zebrafish Brain
por: Wong, Chee Ern David, et al.
Publicado: (2020)

Reawakening GDNF's regenerative past in mice and humans
por: Samos, Andres, et al.
Publicado: (2022)

GDNF Therapy: Can We Make It Work?
por: Björklund, Anders
Publicado: (2021)

Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats
por: Lin, Jia-Piao, et al.
Publicado: (2018)

Acute stress disrupts intestinal homeostasis via GDNF‐RET
por: Lin, Lin, et al.
Publicado: (2020)

The role of transcription factor Runx2 in tumor infiltrating T cells
por: Mbofung, Rina, et al.
Publicado: (2013)

Runx2 contributes to the regenerative potential of the mammary epithelium
por: Ferrari, Nicola, et al.
Publicado: (2015)

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease
por: Penttinen, Anna-Maija, et al.
Publicado: (2018)

Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB — GRB2/ERK/RUNX2 pathway
por: Tang, Yulong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3oao8f67nh9i3765hl3aiq4dv6