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Activation of GDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bone cancer pain

Bone cancer pain is a common symptom in cancer patients with bone metastases and its underlying mechanisms remain unknown. Here, we report that Runx1 directly upregulates the transcriptional activity of P2X3 receptor (P2X3R) gene promoter in PC12 cells. Knocking down Runx1 in dorsal root ganglion (D...

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Detalles Bibliográficos
Autores principales:	Yuan, Zhu-Lin, Liu, Xiao-Dan, Zhang, Zi-Xian, Li, Song, Tian, Yue, Xi, Ke, Cai, Jie, Yang, Xiao-Mei, Liu, Min, Xing, Guo-Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441333/ https://www.ncbi.nlm.nih.gov/pubmed/36072549 http://dx.doi.org/10.1016/j.isci.2022.104936

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