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Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease

Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized b...

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Autores principales: Minocha, Tarun, Birla, Hareram, Obaid, Ahmad A., Rai, Vipin, Sushma, P., Shivamallu, Chandan, Moustafa, Mahmoud, Al-Shehri, Mohammed, Al-Emam, Ahmed, Tikhonova, Maria A., Yadav, Sanjeev Kumar, Poeggeler, Burkhard, Singh, Divakar, Singh, Sandeep Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441372/
https://www.ncbi.nlm.nih.gov/pubmed/36071869
http://dx.doi.org/10.1155/2022/6038996
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author Minocha, Tarun
Birla, Hareram
Obaid, Ahmad A.
Rai, Vipin
Sushma, P.
Shivamallu, Chandan
Moustafa, Mahmoud
Al-Shehri, Mohammed
Al-Emam, Ahmed
Tikhonova, Maria A.
Yadav, Sanjeev Kumar
Poeggeler, Burkhard
Singh, Divakar
Singh, Sandeep Kumar
author_facet Minocha, Tarun
Birla, Hareram
Obaid, Ahmad A.
Rai, Vipin
Sushma, P.
Shivamallu, Chandan
Moustafa, Mahmoud
Al-Shehri, Mohammed
Al-Emam, Ahmed
Tikhonova, Maria A.
Yadav, Sanjeev Kumar
Poeggeler, Burkhard
Singh, Divakar
Singh, Sandeep Kumar
author_sort Minocha, Tarun
collection PubMed
description Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized by cognitive dysfunctions, behavioural disability, and psychological impairments due to the accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles (NFT). Several research reports have shown that flavonoids are the polyphenolic compounds that significantly improve cognitive functions and inhibit or delay the amyloid beta aggregation or NFT formation in AD. Current research has uncovered that dietary use of flavonoid-rich food sources essentially increases intellectual abilities and postpones or hinders the senescence cycle and related neurodegenerative problems including AD. During AD pathogenesis, multiple signalling pathways are involved and to target a single pathway may relieve the symptoms but not provides the permanent cure. Flavonoids communicate with different signalling pathways and adjust their activities, accordingly prompting valuable neuroprotective impacts. Flavonoids likewise hamper the movement of obsessive indications of neurodegenerative disorders by hindering neuronal apoptosis incited by neurotoxic substances. In this short review, we briefly discussed about the classification of flavonoids and their neuroprotective properties that could be used as a potential source for the treatment of AD. In this review, we also highlight the structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production.
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spelling pubmed-94413722022-09-06 Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease Minocha, Tarun Birla, Hareram Obaid, Ahmad A. Rai, Vipin Sushma, P. Shivamallu, Chandan Moustafa, Mahmoud Al-Shehri, Mohammed Al-Emam, Ahmed Tikhonova, Maria A. Yadav, Sanjeev Kumar Poeggeler, Burkhard Singh, Divakar Singh, Sandeep Kumar Oxid Med Cell Longev Review Article Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized by cognitive dysfunctions, behavioural disability, and psychological impairments due to the accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles (NFT). Several research reports have shown that flavonoids are the polyphenolic compounds that significantly improve cognitive functions and inhibit or delay the amyloid beta aggregation or NFT formation in AD. Current research has uncovered that dietary use of flavonoid-rich food sources essentially increases intellectual abilities and postpones or hinders the senescence cycle and related neurodegenerative problems including AD. During AD pathogenesis, multiple signalling pathways are involved and to target a single pathway may relieve the symptoms but not provides the permanent cure. Flavonoids communicate with different signalling pathways and adjust their activities, accordingly prompting valuable neuroprotective impacts. Flavonoids likewise hamper the movement of obsessive indications of neurodegenerative disorders by hindering neuronal apoptosis incited by neurotoxic substances. In this short review, we briefly discussed about the classification of flavonoids and their neuroprotective properties that could be used as a potential source for the treatment of AD. In this review, we also highlight the structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production. Hindawi 2022-08-28 /pmc/articles/PMC9441372/ /pubmed/36071869 http://dx.doi.org/10.1155/2022/6038996 Text en Copyright © 2022 Tarun Minocha et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Minocha, Tarun
Birla, Hareram
Obaid, Ahmad A.
Rai, Vipin
Sushma, P.
Shivamallu, Chandan
Moustafa, Mahmoud
Al-Shehri, Mohammed
Al-Emam, Ahmed
Tikhonova, Maria A.
Yadav, Sanjeev Kumar
Poeggeler, Burkhard
Singh, Divakar
Singh, Sandeep Kumar
Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
title Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
title_full Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
title_fullStr Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
title_full_unstemmed Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
title_short Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease
title_sort flavonoids as promising neuroprotectants and their therapeutic potential against alzheimer's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441372/
https://www.ncbi.nlm.nih.gov/pubmed/36071869
http://dx.doi.org/10.1155/2022/6038996
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