Cargando…

Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria

In recent years, the incidence of pneumonia caused by multidrug-resistant (MDR) Gram-negative bacteria (G−) has increased year by year. Polymyxin B has a good clinical effect in the treatment of MDR, but there is controversy about the administration route of this drug. In this study, we retrospectiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Hanlu, Liu, Xiaobo, Sun, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441374/
https://www.ncbi.nlm.nih.gov/pubmed/36072613
http://dx.doi.org/10.1155/2022/5244538
_version_ 1784782558712561664
author Lin, Hanlu
Liu, Xiaobo
Sun, Pengfei
author_facet Lin, Hanlu
Liu, Xiaobo
Sun, Pengfei
author_sort Lin, Hanlu
collection PubMed
description In recent years, the incidence of pneumonia caused by multidrug-resistant (MDR) Gram-negative bacteria (G−) has increased year by year. Polymyxin B has a good clinical effect in the treatment of MDR, but there is controversy about the administration route of this drug. In this study, we retrospectively analyzed the clinical data of 84 cases of MDR Gram-negative bacterial pneumonia, and aimed to explore the effects of aerosol inhalation combined with intravenous polymyxin B infusion on the bacterial clearance, symptom improvement, and serum infection indexes of MDR patients on the patients with Gram-negative (G−) bacterial pneumonia. The results show that aerosol inhalation combined with intravenous drip of polymyxin B can improve bacterial clearance rate, reduce levels of serum inflammatory factors, and improve clinical symptoms in patients with pneumonia induced by MDR G-bacteria.
format Online
Article
Text
id pubmed-9441374
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-94413742022-09-06 Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria Lin, Hanlu Liu, Xiaobo Sun, Pengfei Emerg Med Int Research Article In recent years, the incidence of pneumonia caused by multidrug-resistant (MDR) Gram-negative bacteria (G−) has increased year by year. Polymyxin B has a good clinical effect in the treatment of MDR, but there is controversy about the administration route of this drug. In this study, we retrospectively analyzed the clinical data of 84 cases of MDR Gram-negative bacterial pneumonia, and aimed to explore the effects of aerosol inhalation combined with intravenous polymyxin B infusion on the bacterial clearance, symptom improvement, and serum infection indexes of MDR patients on the patients with Gram-negative (G−) bacterial pneumonia. The results show that aerosol inhalation combined with intravenous drip of polymyxin B can improve bacterial clearance rate, reduce levels of serum inflammatory factors, and improve clinical symptoms in patients with pneumonia induced by MDR G-bacteria. Hindawi 2022-08-28 /pmc/articles/PMC9441374/ /pubmed/36072613 http://dx.doi.org/10.1155/2022/5244538 Text en Copyright © 2022 Hanlu Lin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Hanlu
Liu, Xiaobo
Sun, Pengfei
Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria
title Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria
title_full Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria
title_fullStr Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria
title_full_unstemmed Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria
title_short Effects of Aerosol Inhalation Combined with Intravenous Drip of Polymyxin B on Bacterial Clearance, Symptoms Improvement, and Serum Infection Indexes in Patients with Pneumonia Induced by Multidrug-Resistant Gram-Negative Bacteria
title_sort effects of aerosol inhalation combined with intravenous drip of polymyxin b on bacterial clearance, symptoms improvement, and serum infection indexes in patients with pneumonia induced by multidrug-resistant gram-negative bacteria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441374/
https://www.ncbi.nlm.nih.gov/pubmed/36072613
http://dx.doi.org/10.1155/2022/5244538
work_keys_str_mv AT linhanlu effectsofaerosolinhalationcombinedwithintravenousdripofpolymyxinbonbacterialclearancesymptomsimprovementandseruminfectionindexesinpatientswithpneumoniainducedbymultidrugresistantgramnegativebacteria
AT liuxiaobo effectsofaerosolinhalationcombinedwithintravenousdripofpolymyxinbonbacterialclearancesymptomsimprovementandseruminfectionindexesinpatientswithpneumoniainducedbymultidrugresistantgramnegativebacteria
AT sunpengfei effectsofaerosolinhalationcombinedwithintravenousdripofpolymyxinbonbacterialclearancesymptomsimprovementandseruminfectionindexesinpatientswithpneumoniainducedbymultidrugresistantgramnegativebacteria