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Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7

In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of infla...

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Detalles Bibliográficos
Autores principales: Wang, Yunxia, Zhou, Yi, Lin, Hui, Chen, Haiyan, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441402/
https://www.ncbi.nlm.nih.gov/pubmed/36072982
http://dx.doi.org/10.1155/2022/7498771
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author Wang, Yunxia
Zhou, Yi
Lin, Hui
Chen, Haiyan
Wang, Shu
author_facet Wang, Yunxia
Zhou, Yi
Lin, Hui
Chen, Haiyan
Wang, Shu
author_sort Wang, Yunxia
collection PubMed
description In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of inflammatory cells, protecting the intestinal mucosal barrier, and inhibiting the growth of colon tumors in the AOM/DSS-induced CAC model. PF also significantly inhibited the expression of TNF-α, IL-1β, IL-6, IL-13, and CEA-related inflammatory factors in the AOM/DSS-induced CAC model by inhibiting the TLR4/NF-κB signaling pathway and EGFL7 expression. Therefore, PF showed a potential therapeutic effect on mice in the CAC model by inhibitingTLR4/NF-κB mediated inflammatory response and EGFL7 expression.
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spelling pubmed-94414022022-09-06 Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 Wang, Yunxia Zhou, Yi Lin, Hui Chen, Haiyan Wang, Shu J Oncol Research Article In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of inflammatory cells, protecting the intestinal mucosal barrier, and inhibiting the growth of colon tumors in the AOM/DSS-induced CAC model. PF also significantly inhibited the expression of TNF-α, IL-1β, IL-6, IL-13, and CEA-related inflammatory factors in the AOM/DSS-induced CAC model by inhibiting the TLR4/NF-κB signaling pathway and EGFL7 expression. Therefore, PF showed a potential therapeutic effect on mice in the CAC model by inhibitingTLR4/NF-κB mediated inflammatory response and EGFL7 expression. Hindawi 2022-08-28 /pmc/articles/PMC9441402/ /pubmed/36072982 http://dx.doi.org/10.1155/2022/7498771 Text en Copyright © 2022 Yunxia Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yunxia
Zhou, Yi
Lin, Hui
Chen, Haiyan
Wang, Shu
Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
title Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
title_full Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
title_fullStr Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
title_full_unstemmed Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
title_short Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
title_sort paeoniflorin inhibits the proliferation and metastasis of ulcerative colitis-associated colon cancer by targeting egfl7
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441402/
https://www.ncbi.nlm.nih.gov/pubmed/36072982
http://dx.doi.org/10.1155/2022/7498771
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