Cargando…
Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7
In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of infla...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441402/ https://www.ncbi.nlm.nih.gov/pubmed/36072982 http://dx.doi.org/10.1155/2022/7498771 |
_version_ | 1784782565998067712 |
---|---|
author | Wang, Yunxia Zhou, Yi Lin, Hui Chen, Haiyan Wang, Shu |
author_facet | Wang, Yunxia Zhou, Yi Lin, Hui Chen, Haiyan Wang, Shu |
author_sort | Wang, Yunxia |
collection | PubMed |
description | In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of inflammatory cells, protecting the intestinal mucosal barrier, and inhibiting the growth of colon tumors in the AOM/DSS-induced CAC model. PF also significantly inhibited the expression of TNF-α, IL-1β, IL-6, IL-13, and CEA-related inflammatory factors in the AOM/DSS-induced CAC model by inhibiting the TLR4/NF-κB signaling pathway and EGFL7 expression. Therefore, PF showed a potential therapeutic effect on mice in the CAC model by inhibitingTLR4/NF-κB mediated inflammatory response and EGFL7 expression. |
format | Online Article Text |
id | pubmed-9441402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94414022022-09-06 Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 Wang, Yunxia Zhou, Yi Lin, Hui Chen, Haiyan Wang, Shu J Oncol Research Article In this study, we studied the therapeutic potential of PF in mouse models of CAC. PF could inhibit the proliferation, migration, invasion, and clone formation and promote the apoptosis of colon cancer cells. Furthermore, PF showed a good effect on inhibiting the aggregation and infiltration of inflammatory cells, protecting the intestinal mucosal barrier, and inhibiting the growth of colon tumors in the AOM/DSS-induced CAC model. PF also significantly inhibited the expression of TNF-α, IL-1β, IL-6, IL-13, and CEA-related inflammatory factors in the AOM/DSS-induced CAC model by inhibiting the TLR4/NF-κB signaling pathway and EGFL7 expression. Therefore, PF showed a potential therapeutic effect on mice in the CAC model by inhibitingTLR4/NF-κB mediated inflammatory response and EGFL7 expression. Hindawi 2022-08-28 /pmc/articles/PMC9441402/ /pubmed/36072982 http://dx.doi.org/10.1155/2022/7498771 Text en Copyright © 2022 Yunxia Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Yunxia Zhou, Yi Lin, Hui Chen, Haiyan Wang, Shu Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 |
title | Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 |
title_full | Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 |
title_fullStr | Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 |
title_full_unstemmed | Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 |
title_short | Paeoniflorin Inhibits the Proliferation and Metastasis of Ulcerative Colitis-Associated Colon Cancer by Targeting EGFL7 |
title_sort | paeoniflorin inhibits the proliferation and metastasis of ulcerative colitis-associated colon cancer by targeting egfl7 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441402/ https://www.ncbi.nlm.nih.gov/pubmed/36072982 http://dx.doi.org/10.1155/2022/7498771 |
work_keys_str_mv | AT wangyunxia paeoniflorininhibitstheproliferationandmetastasisofulcerativecolitisassociatedcoloncancerbytargetingegfl7 AT zhouyi paeoniflorininhibitstheproliferationandmetastasisofulcerativecolitisassociatedcoloncancerbytargetingegfl7 AT linhui paeoniflorininhibitstheproliferationandmetastasisofulcerativecolitisassociatedcoloncancerbytargetingegfl7 AT chenhaiyan paeoniflorininhibitstheproliferationandmetastasisofulcerativecolitisassociatedcoloncancerbytargetingegfl7 AT wangshu paeoniflorininhibitstheproliferationandmetastasisofulcerativecolitisassociatedcoloncancerbytargetingegfl7 |