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Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis

Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are invol...

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Autores principales: Fan, Ni, Fu, Hui, Feng, Xuchen, Chen, Yatong, Wang, Jingyu, Wu, Yuqi, Bian, Yuhong, Li, Yingpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441491/
https://www.ncbi.nlm.nih.gov/pubmed/36072431
http://dx.doi.org/10.3389/fmolb.2022.941653
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author Fan, Ni
Fu, Hui
Feng, Xuchen
Chen, Yatong
Wang, Jingyu
Wu, Yuqi
Bian, Yuhong
Li, Yingpeng
author_facet Fan, Ni
Fu, Hui
Feng, Xuchen
Chen, Yatong
Wang, Jingyu
Wu, Yuqi
Bian, Yuhong
Li, Yingpeng
author_sort Fan, Ni
collection PubMed
description Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are involved in the ten hallmarks of cancer, interestingly, they are also closely associated with aerobic glycolysis. However, the mechanism of this process is non-transparent to date. Demonstrating the mechanism of lncRNAs regulating tumorigenesis and tumor progression through aerobic glycolysis is particularly critical for cancer therapy, and may provide novel therapeutic targets or strategies in cancer treatment. In this review, we discuss the role of lncRNAs and aerobic glycolysis in tumorigenesis and tumor progression, and further explore their interaction, in hope to provide a novel therapeutic target for cancer treatment.
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spelling pubmed-94414912022-09-06 Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis Fan, Ni Fu, Hui Feng, Xuchen Chen, Yatong Wang, Jingyu Wu, Yuqi Bian, Yuhong Li, Yingpeng Front Mol Biosci Molecular Biosciences Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without evident protein-encoding function. LncRNAs are involved in the ten hallmarks of cancer, interestingly, they are also closely associated with aerobic glycolysis. However, the mechanism of this process is non-transparent to date. Demonstrating the mechanism of lncRNAs regulating tumorigenesis and tumor progression through aerobic glycolysis is particularly critical for cancer therapy, and may provide novel therapeutic targets or strategies in cancer treatment. In this review, we discuss the role of lncRNAs and aerobic glycolysis in tumorigenesis and tumor progression, and further explore their interaction, in hope to provide a novel therapeutic target for cancer treatment. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9441491/ /pubmed/36072431 http://dx.doi.org/10.3389/fmolb.2022.941653 Text en Copyright © 2022 Fan, Fu, Feng, Chen, Wang, Wu, Bian and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Fan, Ni
Fu, Hui
Feng, Xuchen
Chen, Yatong
Wang, Jingyu
Wu, Yuqi
Bian, Yuhong
Li, Yingpeng
Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
title Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
title_full Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
title_fullStr Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
title_full_unstemmed Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
title_short Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
title_sort long non-coding rnas play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441491/
https://www.ncbi.nlm.nih.gov/pubmed/36072431
http://dx.doi.org/10.3389/fmolb.2022.941653
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