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Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma
Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects adolescent and young adults. It has high risk for relapse and over the last four decades no improvement of prognosis was achieved. It is therefore crucial to identify new drug candidates for OS treatment to combat drug...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441498/ https://www.ncbi.nlm.nih.gov/pubmed/36072341 http://dx.doi.org/10.3389/fcell.2022.948097 |
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author | Lai, Hong Toan Naumova, Nataliia Marchais, Antonin Gaspar, Nathalie Geoerger, Birgit Brenner, Catherine |
author_facet | Lai, Hong Toan Naumova, Nataliia Marchais, Antonin Gaspar, Nathalie Geoerger, Birgit Brenner, Catherine |
author_sort | Lai, Hong Toan |
collection | PubMed |
description | Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects adolescent and young adults. It has high risk for relapse and over the last four decades no improvement of prognosis was achieved. It is therefore crucial to identify new drug candidates for OS treatment to combat drug resistance, limit relapse, and stop metastatic spread. Two acquired hallmarks of cancer cells, mitochondria-related regulated cell death (RCD) and metabolism are intimately connected. Both have been shown to be dysregulated in OS, making them attractive targets for novel treatment. Promising OS treatment strategies focus on promoting RCD by targeting key molecular actors in metabolic reprogramming. The exact interplay in OS, however, has not been systematically analyzed. We therefore review these aspects by synthesizing current knowledge in apoptosis, ferroptosis, necroptosis, pyroptosis, and autophagy in OS. Additionally, we outline an overview of mitochondrial function and metabolic profiles in different preclinical OS models. Finally, we discuss the mechanism of action of two novel molecule combinations currently investigated in active clinical trials: metformin and the combination of ADI-PEG20, Docetaxel and Gemcitabine. |
format | Online Article Text |
id | pubmed-9441498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94414982022-09-06 Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma Lai, Hong Toan Naumova, Nataliia Marchais, Antonin Gaspar, Nathalie Geoerger, Birgit Brenner, Catherine Front Cell Dev Biol Cell and Developmental Biology Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects adolescent and young adults. It has high risk for relapse and over the last four decades no improvement of prognosis was achieved. It is therefore crucial to identify new drug candidates for OS treatment to combat drug resistance, limit relapse, and stop metastatic spread. Two acquired hallmarks of cancer cells, mitochondria-related regulated cell death (RCD) and metabolism are intimately connected. Both have been shown to be dysregulated in OS, making them attractive targets for novel treatment. Promising OS treatment strategies focus on promoting RCD by targeting key molecular actors in metabolic reprogramming. The exact interplay in OS, however, has not been systematically analyzed. We therefore review these aspects by synthesizing current knowledge in apoptosis, ferroptosis, necroptosis, pyroptosis, and autophagy in OS. Additionally, we outline an overview of mitochondrial function and metabolic profiles in different preclinical OS models. Finally, we discuss the mechanism of action of two novel molecule combinations currently investigated in active clinical trials: metformin and the combination of ADI-PEG20, Docetaxel and Gemcitabine. Frontiers Media S.A. 2022-08-22 /pmc/articles/PMC9441498/ /pubmed/36072341 http://dx.doi.org/10.3389/fcell.2022.948097 Text en Copyright © 2022 Lai, Naumova, Marchais, Gaspar, Geoerger and Brenner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Lai, Hong Toan Naumova, Nataliia Marchais, Antonin Gaspar, Nathalie Geoerger, Birgit Brenner, Catherine Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
title | Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
title_full | Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
title_fullStr | Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
title_full_unstemmed | Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
title_short | Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
title_sort | insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441498/ https://www.ncbi.nlm.nih.gov/pubmed/36072341 http://dx.doi.org/10.3389/fcell.2022.948097 |
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